Hcy、hs-CRP及IL-6在急性脑梗死患者中表达的临床意义

目的 观察超敏C-反应蛋白（hs-CRP）、同型半胱氨酸（Hcy）及白介素-6（IL-6）在急性脑梗死患者中表达的临床意义.方法 收集2011年1月～2013年10月在我院神经内科收治的急性脑梗死患者79例,选取同期健康体检无各种急慢性病者85例为对照组.结果 与对照组比较,入院时,急性脑梗死组的Hcy、hs-CRP和IL-6显著增高（P＜0.01）,人院治疗1d,Hcy、hs-CRP和IL-6显著升高（P＜0.05）,治疗5d稍有降低（P＜0.05）,至治疗10 d恢复至对照组水平（P＞0.05）.Hcy与hs-CRP、Hcy与IL-6和hs-CRP与IL-6呈正相关关系（P＜ 0.01）.治疗期间,共计7例患者死亡,与治疗前比较,治疗10 d后NIHSS评分显著降低（26.4±3.9 vs 15.2±4.2,P＜0.05）.结论 hs-CRP、Hcy和IL-6的变化对急性脑梗死的诊断、治疗和预后有重要的参考意义.

The clinical significance of the expressions of hs-CRP,Hcy and IL-6 in patients with acute cerebral infarction

Objective To investigate the high-sensitivity C-reactive protein （hs-CRP）, homocysteine （Hcy） and Inter- leukin-6 （IL-6） expression in patients with acute cerebral infarction. Methods From January 2011 to October 2013, 79 cases of acute cerebral infarction patients in our hospital were enrolled in our study. 85 cases of healthy people were collected as control. Hcy, hs-CRP and IL-6 were tested before and after treatment. Results Compared with the control, Hcy, hs-CRP and IL-6 were higher when admission （P 〈 0.01）, 1 day of hospitalization, compared with admission, Hcy, hs-CRP and IL-6 were significantly higher （P 〈 0.05）. After 4 days＇ treatment, I-Icy, hs-CRP and IL-6 were decreased （P 〈 0.05）. After 9 days＇ treatment, Hcy, hs-CRP and IL-6 were decreased to normal. Hcy and hs-CRP, Hcy and IL-6, Hcy and IL-6 were positively correlated （P 〈 0.01）. During treatment, seven cases of patients died. Compared with pro-treatment, after 9 days＇ treatment, NIHSS score was significantly lower （26.4±3.9 vs 15.2±4.2,P 〈 0.05）. Conclusion The hs-CRP, Hcy and IL-6 have important reference value in diagnosis and treatment of acute cerebral infarction.