布地奈德和盐酸氨溴索合用雾化吸入治疗小儿毛细支气管炎的临床疗效观察

目的观察并分析布地奈德和盐酸氨溴索合用雾化吸入治疗小儿毛细支气管炎的临床疗效。方法 120例毛细支气管炎患儿随机分为观察组和对照组各60例,两组均予抗感染、吸氧、止咳、平喘等对症支持治疗,观察组同时联合布地奈德混悬液0.5 mg,盐酸氨溴索7.5 mg,氧气驱动雾化吸入,每日2次,每次10~15 min,疗程5~7 d。比较两组治疗后的疗效及两组患儿的主要临床症状、体征的消失时间。结果两组患儿治疗后其临床症状明显好转,观察组的总有效率95.0%,明显高于对照组(χ2=6.387,P<0.05)。观察组患儿咳嗽、气喘及肺部哮鸣音、湿啰音的消失时间明显短于对照组(2.71±0.29)d、(5.16±0.48)d、(3.86±0.41)d、(4.81±0.37)d vs(3.52±0.37)d、(6.38±0.39)d、(5.61±0.68)d、(6.98±0.53)d,P<0.05]。结论布地奈德、盐酸氨溴索合用雾化吸入治疗小儿毛细支气管炎后的疗效明显优于常规治疗的疗效,且明显改善患儿的临床症状,值得广泛推广和应用。

Clinical efficacy of budesonide and ambroxol hydrochloride combination inhalation therapy in children with bronchiolitis

Objective To observe the clinical efficacy of budesonide and ambroxol hydrochloride combination inhalation therapy in children with bronchiolitis. Methods One hundred and twenty children with bronchiolitis were randomly divided into observation group and control group with 60 cases in each,two groups were treated antibiotics, oxygen, cough,asthma and other symptomatic and supportive treatment, the observation group added budesonide suspension 0.5 mg, ambroxol hydrochloride 7.5 rag, oxygen driven inhalation, 2 times a day, 10-15 min, treatment 5 to 7 days.The main clinical symptom efficacy and disappearing time were compared. Results After treatment, both groups of children with clinical symptoms improved markedly, the total efficiency of 95% in the observation group was significantly higher （x2=6.387,P〈0.05）. Observation group of children coughing, wheezing and lung wheeze,rales disappeared significantly shorter than the control group（2.71±0.29）d, （5.16±0.48）d, （3.86±0.41）d, （4.81±0.37）d vs （3.52±0.37）d, （6.38±0.39） d, （5.61±0.68）d, （6.98±0.53）d,P〈0.05]. Conclusion Budesonide and ambroxol inhalation therapy children with bronchiolitis is significantly better than conventional symptomatic treatment,and significantly improve the clinical symptoms,should be popularized and applied.