小剂量普奈洛尔预防肝硬化食管胃底静脉曲张破裂出血的疗效研究

目的探讨小剂量心得安预防食管静脉曲张再出血的疗效。方法对50例治疗组患者和50例对照组患者进行前瞻性对照研究,在用药前后用彩色多普勒超声仪检测其门静脉系统血流动力学的变化,并动态监测患者的基础心率及EVB复发情况。结果用药1个月后治疗组门静脉内径、基础心率显著下降,分别下降为(1.30±0.22)cm、(57.0±4.2)次/min,与用药前比较有显著差异。随访1年,实验组再出血率明显少于对照组。结论小剂量心得安预防EVB复发是安全有效的,值得在临床进一步研究和试用。

The efficacy of low dose propranolol for prevention of esophageal variceal bleeding

Objective To assess the efficacy of low dose propranolol in the prevention of esophageal variceal bleeding. Methods A prospective controlled study was conducted in the treated group（50 cases）, and the control group（50 cases）, by detecting the portal system hemodynamics in patients with portal hypertension and esophageal varices used color Doppler ultrasound technique. Meanwhile the heart rate and partal vein diameter were observed. Results After 1 months administration of the drugs, the heart rate and the diameter of partal vein ewre significantly decreased with the values of（1.30±0.22） cm and（57.0±4.2） bpm, respectively. In the follow-up period of 1 year, the rebleeding rate of the treated group was less than the control group. Conclusion Low dose propranolol is a effective therapy in preventing recurrent esophageal variceal bleeding, and worth further study.