多西他赛联合表柔比星治疗晚期乳腺癌的临床分析

目的观察多西他赛联合表柔比星治疗晚期乳腺癌的疗效及毒副反应。方法回顾性分析45例晚期乳腺癌患者的化疗资料,多西他赛75mg/m2,第1天,表柔比星50mg/m2,第2、3天,21d为1个化疗周期,2个周期后评价疗效。结果全部病例均完成2个周期以上的化疗。CR6例(13.3%),PR17例(37.8%),SD 17例(37.8%),PD5例(11.1%)。RR为51.1%。主要副反应为中性粒细胞减少、恶心呕吐,其它不良反应为腹泻、脱发、肌肉疼痛、心脏和神经毒性。结论多西他赛联合表柔比星治疗晚期乳腺癌疗效较好,不良反应可耐受,但应重视毒副反应的防治。

Docetaxel Combined with Epirubicin in Treatment of Advanced Breast Cancer

Objective To investigate efficacy and toxicities of Docetaxel combined with pirubicin in treatment of advanced breast cancer.Method 45 pationts with advanced breast cancer were given DOC 75mg/m2,d1,E-ADM 50mg/m2,d2,3,21 days was one cycle.Evaluate the curative effect after 2 cycles.Result All cases were completed at least 2 cycles.CR 6（13.3%）,PR 17（37.8%）,SD 17（37.8%）,PD5（11.1%）,RR 51.1%.Main side effect was neutropenia,nausea.The others were diarrhea,hair loss,and muscle pain,heart and nerve toxicity.Conclusion Docetaxel combines epirubicin regimen for MBC has good curative effect;adverse reactions can be tolerated,but should pay attention to the side reaction.