| 急性冠状动脉综合征患者血清胶原降解成分的变化及其意义 |
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| 引用本文： | 舒平,刘迪,周惠云.急性冠状动脉综合征患者血清胶原降解成分的变化及其意义[J].中国心血管杂志,2005,10(3):183-185. |
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| 作者姓名： | 舒平 刘迪 周惠云 |
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| 作者单位： | 北京大学深圳医院急诊科,广东,深圳,518036 |
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| 摘 要： | 目的探讨急性冠状动脉综合征(ACS)患者血清胶原降解产物水平与斑块稳定性的关系。方法ACS患者63例其中急性心肌梗死(AMI)29例,不稳定型心绞痛(UAP)34例]、稳定型心绞痛(SAP)患者38例及正常人20例。采用放射免疫法检测血清Ⅰ和Ⅲ型胶原羧基末端终肽(ⅠCTP、ⅢCTP)、Ⅳ型胶原(Ⅳ-C)、层粘连蛋白(LN)。结果ACS组患者的血清ⅠCTP、ⅢCTP、ⅣC、LN浓度明显高于SAP组及正常组(P<0.001),其中AMI组较UAP组更高,但无显著差异。结论ACS患者的血清胶原降解产物明显升高,可以作为判断斑块不稳定性的生化标记物之一。
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| 关 键 词： | 急性冠状动脉综合征 Ⅰ Ⅲ型胶原羧基末端终肽 Ⅳ型胶原 层粘连蛋白 |
| 文章编号： | 1007-5410(2005)03-0183-03 |
| 修稿时间： | 2004年10月25 |
Changes of serum collagen degradation in patients with acute coronary syndrome and its clinical significance |
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| SHU Ping,LIU Di,ZHOU Hui-yun.Changes of serum collagen degradation in patients with acute coronary syndrome and its clinical significance[J].Chinese Journal of Cardiovascular Medicine,2005,10(3):183-185. |
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| Authors: | SHU Ping LIU Di ZHOU Hui-yun |
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| Institution: | SHU Ping,LIU Di,ZHOU Hui-yun. Department of Emergency,Peking University Shenzhen Hospital,Shenzhen 518036,China |
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| Abstract: | Objective To investigate the relationship between collagen degradation and the stability of plaque. Methods 63 patients with acute coronary syndrome (acute myocardial infraction,n=29; unstable angina pectoris,n=34),stable angina pectoris (n=38) and the control group (n=20) were enrolled. The serum carboxytrminal telepeptide ofⅠand Ⅲtype collagen(ⅠCTP,ⅢCTP), Ⅳcollagen(Ⅳ-C ) and laminin (LN )concentration were determined by radio-immunoassay. Results The levels of serum ⅠCTP, ⅢCTP, Ⅳ-C and LN in ACS group were higher than those in stable angina pectoris group and normal controls(P<0.01). Conclusion The serum collagen degradation is markedly raised in patients with ACS, it may be a new candidate marker of ACS. |
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| Keywords: | Acute coronary syndrome Carboxytrminal telepeptide ofⅠand Ⅲtype collagen Ⅳ collagen Laminin |
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