急性早幼粒细胞白血病合并弥散性血管内凝血(附30例报告)

回顾性分析30例APL并发DIC患者的治疗过程,显示颅内出血为其主要致命性并发症。D-D是高可信度检测指标;APTT易受多种因素影响,如果一项延长,超过正常对照2.5倍以上,高度提示肝素过量。亚临床型DIC应给予小剂量肝素持续静滴;对进展期DIC应同时输注血液制品;确有纤溶亢进时应给予抗纤溶治疗。

The treatment of patients wth acute promyelocytic leukemia complicated with disseminated intiavascular coagalation:report of 30 cases

Analyzed retrospectively the treatment of 30 patients with acute promyelocytic leukemia complicated with disseminated intravascular coagulation (DIC). The result showed that intracerebral hemorrhage was the most serious and fatal complication.For detection of D1C,D D is a highly credible marker;There are a lot of factors which will affect the detection of APTT,if APTT was prolonged barely,and 2.5 times or more than the normal control, overdose of heparin using was to be highly hinted.To patients with sub clinical DIC, we may give low dose heparin, intravenous drip continuousely; To patients with progressing DIC, we may give the transfusion of production from blood If patients with hyperfibrinolysis are confirmed, anti fibrinolysis therapy should be used.