| 精神发育迟滞群体中X连锁型的构成 |
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| 引用本文： | 邵常顺,魏建军.精神发育迟滞群体中X连锁型的构成[J].中华医学遗传学杂志,1994,11(2):81-84. |
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| 作者姓名： | 邵常顺 魏建军 |
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| 作者单位： | 山东医科大学医学遗传教研室 |
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| 基金项目： | 山东省自然科学基金,卫生部启动基金 |
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| 摘 要： | 对群体调查收集到的３８１个非特异性精神发育迟滞（ＭＲ）家庭进行了性别构成分析和分离分析，结果表明男性患者远多于女性患者，尤以中度ＭＲ组明显，分离分析也揭示在中度ＭＲ组男性患者的分离比最高。假定超出的男性患者由Ｘ连锁基因引起，估算出Ｘ连锁型ＭＲ在总体ＭＲ中占２５％，占中度ＭＲ的３０％。就Ｘ连锁基因在ＭＲ发病中的作用进行了讨论。
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| 关 键 词： | 精神发育迟滞，X连锁，遗传 |
CONTRIBUTION OF X-LINKED GENES IN THE NON-SPECIFIC MENTAL RETARDATION ASCERTAINED THROUGH GENERAL POPULATION SURVEY |
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| Shao Changshun,Wei Jianjun,Gong Yaoqin,et al..CONTRIBUTION OF X-LINKED GENES IN THE NON-SPECIFIC MENTAL RETARDATION ASCERTAINED THROUGH GENERAL POPULATION SURVEY[J].Chinese Journal of Medical Genetics,1994,11(2):81-84. |
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| Authors: | Shao Changshun Wei Jianjun Gong Yaoqin |
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| Abstract: | Three hundred eighty one famllies with non-specific mental retardation ascertained through general population survey were analyzed for the contribution of X-linked genes.The excess of males accounted for 25% of the total group and for 30% of the moderate MR group; segregation analysis also revealed higher segregation ratio in the moderate MR male sibs.We estiniated that the XLMR accounts for about 1/4 of the total MR and discussed the disproportionate contribution of the X-chromosome in the etiology of MR. |
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| Keywords: | Mental retardation X-linked inheritance |
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