同型半胱氨酸、癌胚抗原联合检测对男性贲门癌患者的诊断价值

目的 探讨同型半胱氨酸（Hcy）、癌胚抗原（CEA）联合检测对男性贲门癌患者的诊断价值.方法 检测54例贲门癌男性患者和30名健康男性体检者血清Hcy、CEA、糖类抗原（CA） 199、CA724、CA242、组织多肽特异性抗原（TPS）水平的表达,比较联合检测对贲门癌的诊断效果.结果 贲门癌组血清Hcy、CEA水平均高于健康对照组[（20.3±9.2） μmol/L比（13.7±3.1）μmol/L,（7.8±3.5）μg/L比（1.6±1.2）μg/L,均P＜0.05]; CEA、CA199、CA724、CA242、TPS联合检测的灵敏度为73.6％,特异度为64.5％,准确度为70.2％;Hcy、CEA联合检测贲门癌的灵敏度为92.5％,特异度为64.5％,准确度为82.1％,两种组合相互比较差异有统计学意义（P＜0.05）.结论 Hcy、CEA联合检测可能有助于对男性贲门癌诊断和疗效观察.

Diagnostic value of combined examination of homocysteine and CEA for male patients with gastric cardia cancer

Objective To investigate the diagnostic value of combined examination of homocysteine （Hcy） and CEA for male patients with gastric cardia cancer.Methods Serum concentration of Hcy,CEA,CA199,CA724,CA242 and TPS in 54 male patients with gastric cardia cancer and in 30 healthy men were measured.The diagnostic efficacy was analyzed between the combination of Hcy,CEA and the combination of Hcy,CEA,CA199,CA724,CA242,TPS.Results Total Hcy,CEA levels were significantly increased in patients group compared with control group （（20.3±9.2） μmol/L vs （13.7±3.1） μmol/L,（7.8±3.5） μg/L vs （1.6±1.2） μg/L,P 〈 0.05）.The sensitivity,specificity and accuracy of the combination of CEA,CA199,CA724,CA242 and TPS were 73.6 %,64.5 % and 70.2 % respectively,while those of the combination of Hcy,CEA were 92.5 %,64.5 % and 82.1%,respectively.There was significant difference between the combination of Hcy,CEA and the combination of CEA,CA199,CA724,CA242 and TPS （P 〈 0.05）.Conclusion Combined detection of Hcy and CEA is helpful for diagnosis in male patients with gastric cardia cancer.