|
|||||
|
|
| Caspase-1在良性前列腺增生组织中的表达及意义 | |
| 引用本文： | 邓春华,臧志军,孙祥宙,黄晓卉,王浩,王东,苏胜华.Caspase-1在良性前列腺增生组织中的表达及意义[J].中华男科学杂志,2005,11(11):810-812. |
| 作者姓名： | 邓春华 臧志军 孙祥宙 黄晓卉 王浩 王东 苏胜华 |
| 作者单位： | 1. 中山大学,附属第一医院泌尿外科,广东,广州,510080 2. 中山大学,附属第一医院外科实验室,广东,广州,510080 3. 中山大学,医学院病理教研室,广东,广州,510080 4. 中山大学,公共卫生学院,广东,广州,510080 |
| 摘 要： | 目的:探讨正常和良性前列腺增生(BPH)组织中的caspase-1表达情况及意义。方法:应用免疫组化SP法分别检测21例BPH组织和7例正常前列腺组织标本中caspase-1的表达。结果:caspase-1阳性表达率在BPH组织中为71.4%(15/21),正常前列腺组织中为100%(7/7)。BPH上皮组织和间质组织的caspase-1阳性表达均比正常前列腺明显减少(P<0.01)。在BPH组织内部,上皮的caspase-1阳性表达明显高于间质(P<0.01)。结论:caspase-1在BPH组织中的表达较正常前列腺组织显著减少,提示由caspase-1介导的凋亡过程的减少可能参与了BPH的发病过程。 |
| 关 键 词： | 良性前列腺增生 caspase-1 细胞调亡 |
| 文章编号： | 1009-3591（2005）11-0810-03 |
| 收稿时间： | 2005-01-04 |
| 修稿时间： | 2005-04-24 |
Expression and Significance of Caspase-1 in Benign Hyperplastic Prostate Tissues |
|
| DENG Chun-hua,ZANG Zhi-jun,SUN Xiang-zhou,HUANG Xiao-hui,WANG Hao,WANG Dong,SU Sheng-hua.Expression and Significance of Caspase-1 in Benign Hyperplastic Prostate Tissues[J].National Journal of Andrology,2005,11(11):810-812. | |
| Authors: | DENG Chun-hua ZANG Zhi-jun SUN Xiang-zhou HUANG Xiao-hui WANG Hao WANG Dong SU Sheng-hua |
| Institution: | 1. Department of Urology, the First Affiliated Hospital, 2. Surgical Laboratory, the First Affiliated Hospital, 3. Department of Pathology, the First Affiliated Hospital, 4. School of Public Health, Sun Yat-Sen University, Guan- gzhou, Guangdong 510080, China |
| Abstract: | Objective: To investigate the expression and significance of caspase-1 in normal and hyperplastic prostate tissues. Methods: Twenty-eight paraffin-embedded sections,including 21 benign prostatic hyperplasia(BPH) and 7 normal prostate tissue samples,were investigated immunohistochemically for caspase-1.Results: The rate of caspase-1 expression in the BPH tissues was(71.4)%(15/21) while that in the normal prostate tissues was 100%.The expression level of caspase-1 in both epithelial cells and interstitial cells of the hyperplastic prostate tissues was obviously lower than that of the normal prostate tissues(P<(0.01)).Within the BPH tissues,the expression level of caspase-1 in the epithelial cells was higher than in the interstitial cells,and the difference was statistically significant(P<(0.01)).Conclusion: The expression of caspase-1 is dramatically reduced in the hyperplastic prostate tissues,which indicates that the decline of caspase-1-dependent apoptosis might be involved in the progress of benign prostatic hyperplasia.Natl J Androl,2005,11(11):810-812 |
| Keywords: | caspase-1 |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |