可溶性细胞间粘附分子—1与胃癌侵袭关系的研究

目的：探讨胃癌患者外周血中可溶性细胞间粘附分子－1（sICAM-1）与胃癌侵袭转移的关系，方法：通过采用流式细胞仪（FMCS）对胃癌患者外周血中sICAM-1的水平进行定量测定。结果：sICAM-1在胃癌患者血清中的水平明显高于正常对照组（P＜0．01），有肝脏转移癌组明显高于无转移癌组（P＜0．01）。结论sICAM-1做为免疫抑制因子阻断了ICAM－1／LFA－1系统功能，削弱了机体免疫监视能力和对肿瘤细胞的破坏作用，导致肿瘤细胞不断生长和发生远处转移。

Relation between soluble ICAM-1 and gastric cancer invasiveness

Objective To determine the relation between the level of soluble ICAM-1 in the peripheral blood of gas- tric cancer patients and the invasiveness and metastasis of the cancer. Methods FCMS was used to quantify the levels of sICAM--1 in peripheral blood of gastric cancer patients. Results The level of sICAM-1 was significantly higher in the serum of gastric cancer patients than in the normal control group(P<0. 01), and significantly higher in liver metastasis group than in non--metastasis group(P<0. 01 ). Conclusion As an immunological inhibitor, sICAM-1 can block the in- teraction of ICAM--1 and LFA--1, decrease the immunologlcal supervision and cytotoxicity of the body against cancer cells and lead to the overgrowth and metastasis of the cancer.