甘草酸二铵磷脂复合物凝胶治疗小鼠慢性皮炎-湿疹的药效学研究

目的 研究甘草酸二铵磷脂复合物(diammonium glycyrrhizinate phospholipid complex，DG-PC)凝胶对小鼠慢性-皮炎湿疹的治疗作用。方法 采用2,4-二硝基氯苯对小鼠腹部致敏和耳部激发建立慢性皮炎-湿疹模型，千分尺测定右耳中部厚度，分析天平称左右耳片重量，分别计算右耳厚度差和左右耳重量差；光镜下观察小鼠耳组织的病理学变化，采用Image-pro Plus软件统计淋巴细胞数。结果 DG-PC凝胶可有效减轻慢性皮炎-湿疹小鼠耳组织肿胀度，减少淋巴细胞浸润，并能够改善其病理学改变，中剂量组凝胶效果更显著。结论 DG-PC凝胶对小鼠慢性皮炎-湿疹具有治疗作用，该作用非剂量依赖性。

Pharmacodynamic Study of Diammonium Glycyrrhizinate Phospholipid Complex Gels on Mice with Chronic Dermatitis-eczema

OBJECTIVE To evaluate the pharmacodynamic effect of diammonium glycyrrhizinate phospholipid complex (DG-PC) gels on mice with chronic dermatitis-eczema. METHODS The model of mice were established by 2,4-dinitrofluro- benzene. Micrometer was used to measure the central thickness of right ears and analytical balance to measure the weight of both ears. Then pathologic changes of the ear tissues were observed by light microscope, and lymphocytes were counted by Image-pro Plus software. RESULTS DG-PC gels could effectively decrease the ear swelling, reduce the infiltration of lymphocytes and improve the pathologic changes. The gel group of middle dose performed more significant. CONCLUSION DG-PC gels have significant effect on mice with chronic dermatitis-eczema, and the effect is dose-independent.