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| 手性药物代谢动力学的立体选择性 | |
| 引用本文： | 邹巧根,冯振斌,张尊建. 手性药物代谢动力学的立体选择性[J]. 海峡药学, 2011, 0(8): 16-19 |
| 作者姓名： | 邹巧根 冯振斌 张尊建 |
| 作者单位： | 1. 南京工业大学生物与制药工程学院 南京 210009 2. 教育部药物质量与安全预警重点实验室 南京 210009;中国药科大学分析测试中心 南京210009 |
| 摘 要： | 手性是生物体系的一个基本特征。手性大分子物质,如酶、载体、受体、血浆蛋白和多糖等构成了生物体的手性内环境。在体内,手性药物对映体与生物大分子间相互识别、相互作用的立体选择性导致了手性药物在药代动力学方面的立体选择性,其主要表现在手性药物的吸收、分布、代谢和排泄四个过程的差异。 |
| 关 键 词： | 手性药物 药代动力学 立体选择性 |
Stereoselective pharmacokinetics of chiral drugs |
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| ZOU Qiao-gen,FENG Zhen-bin,ZHANG Zun-jian. Stereoselective pharmacokinetics of chiral drugs[J]. Strait Pharmaceutical Journal, 2011, 0(8): 16-19 | |
| Authors: | ZOU Qiao-gen FENG Zhen-bin ZHANG Zun-jian |
| Affiliation: | ZOU Qiao-gen1,FENG Zhen-bin2,3,ZHANG Zun-jian2,3(1.Biological and pharmaceutical engineering institute,Nanjing University of technology Nanjing,210009,China,2.Theministry of education drug quality and safety warning Nanjing 210009,3.Anylysis and test center,China pharmaceutical University,Nanjing 210009,China) |
| Abstract: | Chirality is an essential feature of biological systems.The chiral internal environment of organism consists of various chiral macromolecules,such as enzymes,carriers,receptors,plasma proteins and polysaccharides.In vivo,chiral drugs interaction with chiral biological molecules lead to the stereoselective pharmacokinetics,which mainly reflect in the different properties of absorption,distribution,metabolism and excretion. |
| Keywords: | Chiral drugs Pharmacokinetics Stereoselectivity |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |