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替罗非班治疗急性非ST抬高型心肌梗死的疗效和安全性评价
引用本文:朱玲军,林文辉,张凌志. 替罗非班治疗急性非ST抬高型心肌梗死的疗效和安全性评价[J]. 海峡药学, 2011, 0(8): 115-117
作者姓名:朱玲军  林文辉  张凌志
作者单位:温州医学院附属温岭医院 温岭 317500
摘    要:目的在应用低分子肝素、阿司匹林、氯吡格雷的基础上,研究替罗非班治疗急性非ST抬高型心肌梗死(NSTEAMI)的疗效和安全性。方法对我院2006.1~2010.10的急性非ST抬高型心肌梗死患者200例,在均使用阿司匹林、氯吡咯雷和低分子肝素的基础上,试验组101例给予替罗非班〔负荷量0.4μg/(kg.min)×30min,然后0.1μg/(kg.min)静脉滴注〕,对照组99例给予安慰剂,疗程2d。结果试验组治疗2h后胸痛缓解率、下移ST段恢复率、超敏CRP的下降、心肌酶谱ck-mb峰值提前程度,明显高于对照组(P〈0.05);替罗非班组主要不良反应为出血(发生率10%),与对照组(发生率7%)比较无统计差异(P〉0.05)。结论对于急性非ST抬高型心肌梗死患者,在阿司匹林、氯吡咯雷和低分子肝素治疗基础上,替罗非班可更有效的缓解心肌缺血症状、改善心电图心肌缺血表现,并降低超敏C反应蛋白,且安全性较好。

关 键 词:替罗非班  阿司匹林  氯吡咯雷  低分子肝素  急性非ST抬高型心肌梗死

Effect and safety of tirofiban in the treatment of acute myocardial infarction of no-stelavalation
ZHU Lin-jun,LIN Wen-hui,ZHANG Ling-zhi. Effect and safety of tirofiban in the treatment of acute myocardial infarction of no-stelavalation[J]. Strait Pharmaceutical Journal, 2011, 0(8): 115-117
Authors:ZHU Lin-jun  LIN Wen-hui  ZHANG Ling-zhi
Affiliation:ZHU Lin-jun1,LIN Wen-hui,ZHANG Ling-zhi(Wenling hospital of affiliated Wenzhou medical college,Wenling 317500,China)
Abstract:OBJECTIVE To investigate the efficacy and safety of tirofiban in the treatment of acute myocardial infarction of no-st elavalation on a background of heparin and aspirin therapy.METHODS This was a randomized,double blind and placebo controlled trial.Received concomitant heparin and aspirin,200 patients with acute coronary syndromes were randomized to receive the treatment with tirofiban(load dose 0.4μg/(kg·min)×30min,maintaining dose 0.1μg/(kg·min)(iv drip,n=101) or placebo(n=99) for 2 days.RESULTS There were more obvious improvements in ST segment depression and the number of ischemic leads in the tirofiban group than in the placebo group(P<0.05).There was more reduction in hs-crp in patients with tirofiban(P<0.05).Bleeding occurred in 7% of the patient s receiving placebo and 13% of the patient s receiving tirofiban(P>0.05).CONCLUSION When administered with heparin and aspirin,tirofiban was associated with a lower incidence of ischemic events in patients with acute myocardial infarction of no-st elavalation than in patients who received only heparin and aspirin.
Keywords:Tirofiban  aspirin  Heparin  Acute coronary syndromes  
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