| 帕米膦酸二钠引起严重低钙血症1例 |
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| 引用本文： | 徐贞,史美祺,汤依群.帕米膦酸二钠引起严重低钙血症1例[J].中国临床药理学杂志,2011,27(8). |
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| 作者姓名： | 徐贞 史美祺 汤依群 |
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| 作者单位： | 1. 中国药科大学,临床药学教研室,南京210009
2. 江苏省肿瘤医院肿瘤内科,南京,210009 |
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| 摘 要： | 帕米膦酸二钠用于治疗恶性肿瘤并发的高钙血症和溶骨性癌转移引起的骨痛。1例患者予帕米膦酸二钠90 mg iv,1天后出现全身麻木,呼吸急促,并有窒息感,诊断为严重低钙血症,经对症治疗后病情渐平稳。
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| 关 键 词： | 帕米膦酸二钠 低钙血症 骨瘤 |
Serious hypocalcemia induced by disodium in 1 case |
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| XU Zhen,SHI Mei-qi,TANG Yi-qun.Serious hypocalcemia induced by disodium in 1 case[J].The Chinese Journal of Clinical Pharmacology,2011,27(8). |
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| Authors: | XU Zhen SHI Mei-qi TANG Yi-qun |
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| Institution: | XU Zhen1,SHI Mei-qi2,TANG Yi-qun1(1.Department of Clinical Pharmacology,China Pharmaceutical University,Nanjing 21009,China,Oncology Department,Jiangsu Cancer Hospital,China) |
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| Abstract: | Pamidronate is increasingly used both in the treatment of hypercalcemia and bone pain of osteolytic metastasis in cancer.We describe a case of severe hypocalcemia following one injection of pamidronate.One day after the administration of 90 mg pamidronate,patient felt whole-body numbness,shortness of breath,suffocation or choking.Condition got stable after symptomatic treatment.Prescribers should be thoroughly familiar with this risk of pamidronate disodium,and avoid the occurrence of serious side effects. |
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| Keywords: | pamidronate hypercal cermia bone pain |
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