| 消旋卡多曲治疗成人急性腹泻的临床疗效 |
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| 引用本文： | 姚萍,席利力.消旋卡多曲治疗成人急性腹泻的临床疗效[J].中国临床药理学杂志,2011,27(8). |
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| 作者姓名： | 姚萍 席利力 |
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| 作者单位： | 新疆医科大学,第一附属医院消化科,乌鲁木齐,830054 |
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| 摘 要： | 目的观察消旋卡多曲(抗腹泻药)治疗成人急性腹泻的临床疗效及安全性。方法将109例急性腹泻患者随机分为消旋卡多曲治疗组(55例)和对照组(54例)。对照组用WHO标准化口服补液治疗,纠正电解质和酸碱失衡;治疗组在此基础上,加用消旋卡多曲每次100 mg,每天3次。观察2组临床疗效及不良反应发生情况。结果治疗组大便次数及性质恢复时间较对照组缩短,分别为(33.3±23.96)h vs(64.3±27.32)h;(47.8±10.46)h vs(70.8±12.82)h;脱水、电解质紊乱纠正时间也较对照组明显缩短,分别为(30.7±14.51)h vs(56.0±16.58)h;消旋卡多曲治疗总病程短于对照组,分别为(56.8±20.51)hvs(90.9±21.35)h;治疗72 h后,治疗组总有效率(90.90%)高于对照组(72.22%),差异有统计学意义(P<0.05)。结论常规治疗基础上配合消旋卡多曲治疗,可较快缓解急性腹泻的病情,缩短病程,且安全。
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| 关 键 词： | 消旋卡多曲 急性腹泻 |
Clinical effect of racecadotril tablets for acute diarrhea in adults |
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| YAO Ping,XI Li-li.Clinical effect of racecadotril tablets for acute diarrhea in adults[J].The Chinese Journal of Clinical Pharmacology,2011,27(8). |
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| Authors: | YAO Ping XI Li-li |
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| Institution: | YAO Ping,XI Li-li(Department of Gastroenterology,The First Affiliated Hospital of Xinjiang Medical University,Urumqi 830054,China) |
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| Abstract: | Objective To observe the curative effects of racecadotril tablets for acute diarrhea in adults.Methods One hundred and nine patients with acute diarrhea were randomly divided into racecadotril group(55 cases) and control group(54 cases).The control group was treated only by standardized oral rehydration therapy,and the racecadotril group was treated by racecadotril tablets with the dosage of 100 mg/time,three times a day,based on the standardized oral rehydration therapy.The improvement time of diarrhea and... |
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| Keywords: | racecadotril acute diarrhea |
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