左旋多巴联合卡巴拉汀对帕金森患者认知障碍、运动功能和平衡功能的影响

【目的】探讨左旋多巴联合卡巴拉汀改善帕金森患者认知障碍、运动功能和平衡功能的效果。【方法】选取2016年6月至2018年8月在本院接受治疗的86例帕金森患者为研究对象,采用随机数字表法随机分为对照组和观察组,每组各43例。对照组患者采用左旋多巴治疗,观察组患者采用左旋多巴联合卡巴拉汀治疗,连续治疗6个月。比较两组患者临床症状改善时间、治疗前后认知、运动和平衡功能评分、治疗前后腱反射、肌张力、肌痉挛评分及不良反应情况【结果】治疗后,观察组患者临床症状(.肌强直、运动迟缓、静止性震颤及姿势步行障碍)改善时间明显低于对照组(P<0.05);两组患者阿尔茨海默病评价量表-认知分量表(ADAS-Cog)和统一帕金森病评价量表第三部分(UPDRSID)评分均降低,且观察组明显低于对照组(P<0.05);两组患者Berg平衡功能量表评分均明显升高,且观察组显著高于对照组(P<0.05);两组患者腱反射、肌张力、肌痉挛评分均降低,且观察组明显低于对照组(P<0.05);观察组患者不良反应发生率为11.61%,显著低于对照组的32.54%(P<0.05)。【结论】采用左旋多巴联合卡巴拉汀治疗帕金森患者.疗效确切,可显著改善患者认知障碍、运动功能和平衡功能.安全性也较高,值得临床推广应用。

Effect of Levodopa combined with Carbaratin on Cognitive Impairment,Motor Function and Balance Func-tion in Parkinson's Disease

Objective]To investigate the efee of levodopa combined with carbaratin on cognitive impirment,motor function and balance function in Parkinson's disease.Methods]A total of 86 PD patients treated in our hospital from June 2016 to August 2018 were seleted as the study subjects and randomly divided into control and observation groups by ran-dom number table method,with 43 patients in each group.Patients in the control group were treated with levodopa.and pa-tients in the observation group were treated with levodopa combined with carbaratin continwously for 6 months.The time to clinical improvement.cognitive.motor.and balance function scores.tendon reflexes.muscle tone.and muscle spasms scores.and adverse ffects were compared between the two groups.Results]After treatment.patients in the observation group had significanly less time to improvement in cdinical symptoms(myotonia,bradykinesia,resting tremor and postural walking disorders)than those in the control group(P<0.05);the Alzheimers disease assment scale cognitive subsceale(ADAS C0G)and Unified Parkinson's disease assment scale Part Ⅲ(UPDRS Ⅲ)scores were reduced in both groups.and were significantly lower in the observation group than in the control group(P<0.05);Berg Balance Function Scale scores were significanly higher in both groups,and significantly kigher in the observation group(P<0.05);Tendon refle-xes.musce tone,and muscle spasticity scores were reduced in both groups。and were significantly lower in the observation group than that in the control group(P<0.05);the incidence of adverse events in the observation group was 11.61%,which was significantly lower than that in the control group(32.54%)(P<0.05).Conclusion]The use of levodopa plus carbaratinin patients with Parkinson's disease has definite fficacy.can significantly improve patients'cognitive impairment,motor funetion.and balance function,and the safety profile is also high.which warrants elinical promotion.