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| 血管紧张素转换酶基因的插入/缺失多态性与冠心病关系的研究 | |
| 引用本文： | 顾海彤 张沪生. 血管紧张素转换酶基因的插入/缺失多态性与冠心病关系的研究[J]. 首都医科大学学报, 1998, 19(3): 228-230 |
| 作者姓名： | 顾海彤 张沪生 |
| 作者单位： | 首都医科大学附属北京同仁医院内科 |
| 摘 要： | 运用ＰＣＲ技术对９５例冠心病（ＣＨＤ）患者和１００例健康人的血管紧张素转换酶（ＡＣＥ）基因插入／缺失多态性进行了检测，并与ＣＨＤ发病、血清ＡＣＥ水平、易患因素等指标进行比较。结果：ＣＨＤ组缺失等位基因Ｄ频率为０．５４，ＤＤ基因型频率为０．３５，显著高于对照组的０．３５和０．１３（均Ｐ＜０．０１）。表明ＡＣＥ基因的缺失多态性可能是我国人群ＣＨＤ发病的重要危险因素之一。 |
| 关 键 词： | 血管紧张素转换酶；基因多态性；PCR技术；冠心病 |
| 收稿时间： | 1997-09-05 |
The Relationship between Insertion/deletion Polymorphism of Angiotension converting Enzyme Gene and Coronary Heart Disease |
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| Gu Haitong,Zhang Husheng,Wang Yong,Jiang Yanfang Dept. of Medicine,Tongren Hospital,Affiliate of Capital University of Medical Sciences. The Relationship between Insertion/deletion Polymorphism of Angiotension converting Enzyme Gene and Coronary Heart Disease[J]. Journal of Capital Medical University, 1998, 19(3): 228-230 | |
| Authors: | Gu Haitong Zhang Husheng Wang Yong Jiang Yanfang Dept. of Medicine Tongren Hospital Affiliate of Capital University of Medical Sciences |
| Affiliation: | Dept. of Medicine, Tongren Hospital, Affiliate of Capital University of Medical Sciences |
| Abstract: | Insertion/deletion(I/D) polymorphism of the ACE gene was detected by polymerase chain reaction (PCR) in a study of 100 control subject and 95 patients with coronary heart disease(CHD), and was campared with serum ACE level and CHD morbidity in Beijing population and prodisposing factors. Results: The frenquencies of D allele (0.54) and DD genotype (0.35) were higher among the CHD group than among the control subjects(0.35,0.13,both P <0.01). Conclution: Deletion polymorphism of the ACE gene might be an important risk factor for CHD in Chinese population. |
| Keywords: | angiotension coverting enzyme gene polymorphism PCR coronary heart disease |
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