皮肌炎/多发性肌炎合并间质性肺炎的临床研究

目的：研究皮肌炎/多发性肌炎（DM/PM）合并间质性肺炎的临床特点。方法：对比分析10例DM/PM合并间质性肺炎及26例特发性肺纤维化（IPF）患者的症状、体征、X线胸片、胸部高分辨CT(HRCT)、肺功能、动脉血气结果。结果：DM/PM合并间质性肺炎发病年龄较IPF年轻，发病至就诊时间明显较后者短。两组都有不同程度的低氧血症，无二氧化碳潴留。肺功能检查：以限制为主，均有弥散功能降低。结论：DM/PM合并间质性肺炎发病年龄较IPF年轻，病程较短，存活时间短，预后差。

Clinical Study on Dermatomyositis/Plymyositis Complicated with Interstitial Pneumonitis

Objective To provide theoretic basis for clinical characteristics of interstitial pneumonitis(IP) in dermatomyositis/polymyositis (DM/PM). Methods Clinical markers included causes, clinical characteristics, radiography, high-resolution CT(HRCT), arterial blood gas,lung function, complication and prognosis were compared between 10 patients with IP in DM/PM and 26 patients with idiopathic pulmonary fibrosis(IPF). Results Compared with IPF, patients DM/PM complicated with IP were younger. Patients with IP in DM/PM had shorter disease course, worse prognosis than that in patients with IPF. Pulmonary function test showed restrictive and diffusive dysfunction. Blood gas analysis suggested that there was diffcrent degrees hypoxemia in the two groups.Conclusions The patients with IP in DM/PM was younger than those of the patients with IPF, and have shorter disease course, shorter survival time, worse prognosis.