新疆男男性行为人群高危行为安全套使用状况及其影响因素分析

  目的  了解新疆男男性行为人群（MSM）队列失访率和随访保持率以及分析失访原因。  方法  于2010年6月 — 2015年3月在新疆乌鲁木齐市、伊宁市、阿克苏市3个地区招募HIV抗体阴性MSM，建立前瞻性队列研究。每3个月进行定位随访，每6个月进行行为学调查和HIV抗体检测。单因素分析采用多组比较的χ²检验，多因素分析采用多元logistic回归。  结果  队列共纳入1 041名调查对象，6个月随访人数900人（86.46 %），12个月随访884人（84.92 %）；6个月失访141人（13.54 %），12个月失访157人（15.08 %）.单因素分析结果显示，年龄、文化程度、户籍所在地、月收入、艾滋病相关知识、调查地区、参加队列原因、寻找性伴场所、安全套使用频次、近6个月性伴数量以及感染丙肝状况是MSM失访与随访之间的差异存在统计学意义的变量（P < 0.05）。多因素分析结果显示，文化程度（OR = 0.089，95 % CI = 0.060～0.133，P < 0.001）、调查地区（OR = 1.800，95 % CI = 1.231～2.632，P = 0.002）、参加队列原因（OR = 0.663，95 % CI = 0.465～0.946，P = 0.023）、近6个月性伴数量（OR = 4.070，95 % CI = 2.002～8.278，P < 0.01）是队列失访的影响因素。  结论  新疆MSM队列失访率较高，文化程度、调查地区、参加队列研究的原因以及近6个月性伴数量均与队列失访有关。

Lost to follow-up and its influencing factors among men who have sex with men in a cohort in Xinjiang Uygur Autonomous Region

  Objective  To analyze the rate and associates of lost to follow-up in a cohort of men who have sex with men (MSM) initially negative for human immunodeficiency virus (HIV) in Xinjiang Uygur Autonomous Region (Xinjiang).  Methods  We sequentially recruited 1 041 MSM tested negative for HIV at the time of inclusion in 3 municipality regions of Xinjiang from June 2010 to March 2015 for a prospective cohort study. The participants of the study were followed-up every 3-month and were surveyed with a questionnaire interview on sex behavior and HIV antibody test every 6-month.  Results  For all the participants, the number of being successfully interviewed was 900 and 884 at the time of 6th month and 12th month follow-up, with the ratios of 13.54% and 15.08% for being lost to follow-up, respectively. In univariate analysis, there were significant differences between the participants being followed-up and lost to followed-up in age, education, registered residence, monthly income, knowledge about HIV infection, current residential region, motivation for participating in the survey, setting of seeking sexual partners, frequency of condom use, number of sexual partners during previous 6 months, and hepatitis C virus infection (P < 0.05 for all). Multivariate logistic regression analysis revealed following significant impact factors for lost to followed-up: education (high vs. low: odds ratio [OR] = 0.089, 95% confidence interval [95% CI]: 0.060 – 0.133; P < 0.001), current residential region (metropolis vs. small and medium cities: OR = 1.800, 95% CI: 1.231 – 2.632; P = 0.002), motivation for participating in the survey (to have HIV detection vs. others: OR = 0.663, 95% CI: 0.465 – 0.946; P = 0.023), and the number of sexual partners during previous 6 months (high vs. low: OR = 4.070, 95% CI: 2.002 – 8.278; P < 0.001).  Conclusion  The rate of lost to followed-up is high among MSM involved in a prospective cohort in Xinjiang and the follow up among the MSM is mainly associated with education, current residential region, motivation for the participation and the number of sexual partners.