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| 外周血线粒体DNA拷贝数检测及影响因素 | |
| 引用本文： | 李梦颖, 郭欢. 外周血线粒体DNA拷贝数检测及影响因素[J]. 中国公共卫生, 2021, 37(11): 1704-1708. DOI: 10.11847/zgggws1132373 |
| 作者姓名： | 李梦颖 郭欢 |
| 作者单位： | 1.华中科技大学同济医学院公共卫生学院劳动卫生与环境卫生学系 环境与健康教育部重点实验室 国家环境保护部环境与健康重点实验室，湖北 武汉 430030 |
| 基金项目： | 国家自然科学基金优秀青年科学基金（81722038） |
| 摘 要： | 外周血线粒体DNA拷贝数（mtDNAcn）是反映机体氧化应激状态的新兴生物标志物，越来越多流行病学研究表明外周血mtDNAcn异常与心血管疾病、帕金森、恶性肿瘤等重大慢性疾病发生风险有关。因此，了解mtDNAcn的检测手段、寻找mtDNAcn这一疾病早期生物标志物的影响因素，对慢性病防控有着重要意义。本文针对外周血mtDNAcn相关检测技术和外周血mtDNAcn的影响因素研究进展进行综述，旨在为mtDNAcn疾病早期生物标志物的确定提供依据，为慢性病预防提供技术支撑。 |
| 关 键 词： | 线粒体DNA拷贝数（mtDNAcn） 遗传因素 生活方式 环境污染物 |
| 收稿时间： | 2020-09-08 |
Comprehensive molecular characterization of mitochondrial genomes in human cancers |
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| LI Meng-ying, GUO Huan. Detection and influencing factors of peripheral blood mitochondrial DNA copy number: a review[J]. Chinese Journal of Public Health, 2021, 37(11): 1704-1708. DOI: 10.11847/zgggws1132373 | |
| Authors: | LI Meng-ying GUO Huan |
| Affiliation: | 1.Department of Occupational and Environmental Health, Ministry of Education and Ministry of Environmental Protection Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province 430030, China |
| Abstract: | Peripheral blood mitochondrial DNA copy number (mtDNAcn) is a novel biomarker reflecting oxidative stress status in body. Emerging epidemiological evidences have reported associations of peripheral blood mtDNAcn with major chronic diseases such as cardiovascular diseases, Parkinson's disease, and cancer. It is of great importance to develop methods for measuring peripheral blood mtDNAcn and to identify their risk factors, which could help to promote prevention of chronic diseases. In this study, we introduce detection methods of mtDNAcn and give an outline review on the potential influencing factors of peripheral blood mtDNAcn, aiming to present evidences for identification of peripheral blood mtDNAcn as an early biomarker and to provide technical support for the prevention of chronic diseases. |
| Keywords: | mitochondrial DNA copy number genetic factor lifestyle environmental pollutant |
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