硝苯地平联合乌灵胶囊治疗原发性高血压伴焦虑症状的临床观察

目的：观察硝苯地平联合乌灵胶囊治疗原发性高血压伴焦虑症状的疗效和安全性。方法：将60例原发性高血压伴焦虑症状患者采用随机数字表法均分为两组。对照组患者给予硝苯地平缓释片10mg，bid，同时加服安神补脑液10ml，bid。观察组患者给予硝苯地平缓释片10mg，bid，同时加服乌灵胶囊3粒，tid。两组患者均治疗8周。观察并比较两组患者治疗前后的血压水平、汉密尔顿焦虑量表评分（HAMA）以及不良反应发生情况。结果：治疗后，观察组患者血压下降幅度、HAMA评分均显著优于对照组，两组比较差异有统计学意义（P〈0．01）；观察组患者降压及抗焦虑的总有效率均显著高于对照组，两组比较差异有统计学意义（P〈0．01）；两组患者均未见明显不良反应发生。结论：硝苯地平联合乌灵胶囊治疗原发性高血压伴焦虑症状，在改善患者焦虑症状的同时提高了原发性高血压的治疗效果，且安全性较好。

Clinical Observation of Nifedipine Combined with Wuling Capsule in the Treatment of Primary Hypertension Complicating with Anxiety

OBJECTIVE： To observe therapuetic efficacy and safety of nifedipine combined with Wuling capsule in the treatment of primary hypertension complicating with anxiety. METHODS： 60 patients with primary hypertension complicating with anxiety were randomly divided into control group and treatment group with 30 cases in each group. Control group was given Nifedipine sustained-release tablet 10 mg and Anshen bunao liquid 10 ml orally, twice a day. Observation group was given Nifedipine sustained-release tablet 10 mg orally, twice day, and Wuling capsule, 3 pills each time, 3 times per day. A course of treatment lasted for 8 weeks. RESULTS： The blood pressure of observation group was smoothly significantly decreased after treatment, compared with that of control group （P〈0.01） ; there was statistical significance. The anxiety symptoms were relieved obviously, and HAMA psychological stress score had significant difference between 2 groups after treatment （P〈0.01）. Total effective rate of blood depresure and anti-anxiety in treatment group were higher than that of control group, there was statistical significance （P〈0.01）. No ADR were found in both groups. CONCLUSIONS： Nifedipine combined with Wuling capsule can improve therapeutic efficacy and have good safety in the treatment of primary hypertension compliacting with anxiety.