五麦党黄口服液对辐射损伤模型小鼠免疫功能的影响

目的：研究五麦党黄口服液对辐射损伤模型小鼠免疫功能的影响。方法：40只小鼠随机分为正常对照（等容生理盐水）组、模型（等容生理盐水）组与五麦党黄口服液高、低剂量（14．6、7．3g／kg）组。小鼠灌胃给药，每天1次，连续14d。给药7d后2h后^60Co-γ，射线进行一次性全身照射，剂量为0．667Gy／min，总剂量为2．0Gy，以复制辐射损伤模型。检测小鼠外周血白细胞计数，脾、胸腺指数和刺激指数（SI）。结果：与正常对照组比较，模型组小鼠外周血白细胞计数、脏器指数和SI显著降低（P〈0．01）；与模型组比较，五麦党黄口服液高、低剂量组小鼠外周血白细胞计数显著增加、脾脏指数和SI显著升高（P〈0．01或P〈0．05），五麦党黄口服液高剂量组胸腺指数显著升高（P〈0．05）。结论：五麦党黄口服液对辐射所致小鼠免疫功能损伤有一定的保护和修复作用。

Effects of Wumai Danghuang Oral Liquid on Immune Function of Radiation Damage Model Mice

OBJECTIVE： To study the effects of Wumai Danghuang oral liquid on immune function of irradiation damage mod- el mice. METHODS： 40 mice were randomly divided into normal control group （constant volume of normal saline）, model group （constant volume of normal saline）, Wumai Danghuang oral liquid high-dose and low-dose groups （14.6 g/kg, 7.3 g/kg）. They were given relevant medicines intragastrically once a day for consecutive 14 days. The irradiation damage model was induced by general irradiation with ^60Co-γ-rays, dose rate of 0.667 Gy/min and total dose of 2.0 Gy 2 h after 7 days administration. The number of WBC, spleen index, thymus index, the ability of lymphocytes transformation were examined. RESULTS： Compared with nor- mal control group, the number of WBC, spleen index, the ability of lyrnphocytes transformation in model group were decreased sig- nificantly（P〈0.01 ）. Compared with Wumai Danghuang oral liquid group, the number of WBC, viscera index, the ability of lym- phocyte transformation in Wumai Danghuang oral liquid low-dose and high-dose groups were increased significantly（P〈0.01 or P〈 0.05）, thymusin index in Wumai Danghuang oral liquid high-dose groups were increased significantly（P〈0.05）.CONCLUSIONS： Wumai Danghuang oral liquid has protective effects on immune function of irradiation damage model mice.