Autism and behavior in adult patients with Dravet syndrome (DS) |
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| Affiliation: | 1. Department of Residential Care, Epilepsy Center Kempenhaeghe, Heeze, The Netherlands;2. Department of Neurology, Academic Center for Epileptology Kempenhaeghe/Maastricht University Medical Center, The Netherlands;3. Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands;1. Séguin-Clinik for Persons with Severe Intellectual Disability, Epilepsy Centre Kork, Germany;2. Medical Genetics Center, Munich, Germany;3. Friedrich-Baur-Institute, Munich, Germany;1. Department of Neurology, Epilepsy Center Hessen, Philipps-University, Marburg, Germany;2. Center for Child and Adolescent Medicine, Section Neuropediatrics, Ruprecht-Karls University, Heidelberg, Germany;3. Institute of Medical Sociology and Social Medicine, Philipps-University, Marburg, Germany;4. Department of Pediatric Neurology, Kiel University, Germany;5. Northern German Epilepsy Centre for Children and Adolescents, Raisdorf, Germany |
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| Abstract: | IntroductionAutism and behavioral characteristics in adults with Dravet syndrome (DS) have rarely been systematically studied.MethodThree scales were used to assess the outcomes of DS in adulthood in terms of autism and behavior. All the adult patients with DS, nine male and four female, aged between 18 and 60 years, living at the Epilepsy Center Kempenhaeghe in The Netherlands were included in the study. In addition, the past medical history of each patient was systematically screened for diagnoses like autism, Pervasive Development Disorder-Not Otherwise Specified (PDD-NOS), autism spectrum disorder (ASD), hyperactivity, Attention Deficit Hyperactivity Disorder (ADHD), and self-mutilation. Information concerning past and current use of psychoactive drugs was also evaluated.ResultsEight patients (61.5%) were classified as having autism spectrum disorder (ASD) according to the AVZ-R or according to the medical record. Self-mutilation was seen in four patients (30.8%), hyperactivity in none. Three patients (23.1%) currently used psychoactive drugs.ConclusionAutism spectrum disorders persist in adult patients with DS, while certain characteristics associated with behavioral problems, such as hyperactivity or use of psychoactive medication, seem to be less prominent than in childhood. |
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