Effects of physical activity in telomere length: Systematic review and meta-analysis |
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| Affiliation: | 1. Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Centro Infant, Biomedical Research Institute PUCRS, Porto Alegre, Brazil;2. Programa de Pós-Graduação em Ciências Biológicas: Bioquímica, Departamento de Bioquimica, ICBS, Universidade Federal do Rio Grande do (UFRGS), Porto Alegre, Brazil;3. School of Medicine, Department of Biology and Pharmacy, Universidade de Santa Cruz do Sul (UNISC), Brazil;1. Department of Psychiatry, Tulane University School of Medicine, New Orleans, LA;2. University of Maryland School of Medicine, Baltimore, MD;3. Department of Global Community Health and Behavioral Sciences, Tulane School of Public Health and Tropical Medicine, New Orleans, LA;1. Department of Psychiatry, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil;2. Program for Research and Care on Violence and PTSD (PROVE), Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil;3. Department of Morphology and Genetics, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil;4. LiNC - Laboratory of Integrative Neuroscience, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil;5. Department of Psychiatry, Amsterdam University Medical Centers, Location AMC, Amsterdam Public Health Research Institute and Amsterdam Neuroscience Research Institute, Amsterdam, the Netherlands;6. University of Montana, Missoula, Montana, United States;7. ARQ National Psychotrauma Centre, Diemen, the Netherlands;1. Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore;2. Cancer Science Institute of Singapore, National University of Singapore, Singapore;3. Curtin Health Innovation Research Institute, Biosciences Research Precinct, School of Biomedical Sciences, Faculty of Health Sciences, Curtin University, WA, Australia;4. Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore;5. Memory, Aging and Cognition Centre, National University Health System, Singapore;6. National University Cancer Institute, Singapore;7. Department of Biological Sciences, University of North Texas, Denton, TX, USA;1. The Cambridge Centre for Sport and Exercise Sciences, Anglia Ruskin University, Cambridge, UK;2. Department of Diagnostics and Public Health, University of Verona, Italy;3. Primary Care Department Azienda USL Toscana Sud Est, Grosseto, Italy;4. Kayseri Education and Research Hospital, Geriatric Center, Kayseri, Turkey;5. Physiotherapy Department, South London and Maudsley NHS Foundation Trust, Denmark Hill, London SE5 8AZ, UK;6. Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King’s College London, De Crespigny Park, London, UK;7. School Sport Exercise Health Sciences, Loughborough University, Loughborough, UK;8. Department of Surgery, Section of Pathology, San Bortolo Hospital, Vicenza, Italy;9. ARC-Net Research Center, University of Verona, Verona, Italy;10. Faculty of Sports Sciences, University of Murcia, Spain;11. NICM Health Research Institute, University of Western Sydney, Sydney, Australia;12. Centre for Youth Mental Health, University of Melbourne, Melbourne, Australia;13. Parc Sanitari Sant Joan de Déu/CIBERSAM, Universitat de Barcelona, Fundació Sant Joan de Déu, Sant Boi de Llobregat, Barcelona, Spain;14. Department of Neurology, Medical University of Innsbruck, Austria;15. Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, UK;p. Department of Epidemiology, Center for Public Health, Medical University of Vienna, Austria;q. University College London, Institute of Sport, Exercise and Health, UK;r. Pennine Acute Hospitals, NHS Trust, UK;s. National Research Council, Neuroscience Institute, Aging Branch, Padova, Italy;1. Mood Disorders Research Program and Laboratory for Clinical and Translational Neuroscience, Butler Hospital, Providence, RI, USA;2. Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University, Providence, RI, USA;3. Molecular and Behavioral Neuroscience Institute and Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA |
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| Abstract: | The aim of this systematic review is to assess the effects of exercise on telomeres length. We searched the following databases: MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials (CENTRAL, The Cochrane Library), Scopus, LILACS, SPORTDiscus and Web of Science from inception to August 2014. All articles that assessed the effects of exercise in telomere length were included in this review. The search strategy used the following combinations of terms: telomere AND “motor activity” OR exercise OR “physical activity”. Two reviewers, working independently, screened all titles and abstracts to identify studies that could meet inclusion criteria. Whenever possible, and if appropriate, we performed a random-effect meta-analysis of study outcomes. Thirty-seven original studies were included in this systematic review, including 41,230 participants. Twenty articles did not find statistically significant association, whereas 15 described a positive association. Two papers found an inverted “U” correlation. There is a tendency toward demonstrating an effect of exercise on telomere length. Few prospective studies were found, many studies did not reach statistical significance and there was an important methodological diversity. For this reason, a possible significant association between physical activity and telomere length remains an open question. |
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| Keywords: | Telomere length Physical exercise Physical activity Aging |
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