| 中药肾毒性成分及其毒性机制研究进展 |
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| 引用本文： | 杨立国,乌日拉嘎,萨其拉吐,奥·乌力吉.中药肾毒性成分及其毒性机制研究进展[J].中草药,2023,54(23):7934-7952. |
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| 作者姓名： | 杨立国 乌日拉嘎 萨其拉吐 奥·乌力吉 |
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| 作者单位： | 内蒙古民族大学蒙医药学院, 内蒙古 通辽 028000;蒙药研发国家地方联合工程研究中心, 内蒙古 通辽 028000;内蒙古蒙医药工程技术研究院, 内蒙古 通辽 028000 |
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| 基金项目： | 国家自然科学基金资助项目（82260681）；蒙药研发国家地方联合工程研究中心开放基金资助项目（MDK2023046） |
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| 摘 要： | 近年来，随着我国医药产业的稳步发展，中药作为补充和替代医学制剂在世界各地赢得了认可和信赖。然而，随着对中药的广泛应用和深入研究，中药的肾脏毒性引发了国内外学者的广泛关注。为保障中药临床应用的安全性，有必要深入研究并整理中药肾毒性成分及其毒性机制。在查阅近30年国内外常见中药肾毒性相关文献的基础上，对中药肾毒性成分及其毒性机制进行了总结与分析，以期为中药肾毒性深入研究提供思路，为中药安全合理应用提供参考。
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| 关 键 词： | 中药 肾毒性 毒性成分 毒性机制 安全合理用药 |
| 收稿时间： | 2023/6/8 0:00:00 |
Research progress on nephrotoxic components in traditional Chinese medicine and its toxic mechanisms |
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| YANG Li-guo,Wurilag,Saqilatu,AO.Research progress on nephrotoxic components in traditional Chinese medicine and its toxic mechanisms[J].Chinese Traditional and Herbal Drugs,2023,54(23):7934-7952. |
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| Authors: | YANG Li-guo Wurilag Saqilatu AO |
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| Institution: | College of Mongolian Medicine and Pharmacy, Inner Mongolia Minzu University, Tongliao 028000, China;National and Local Joint Engineering Research Center for Mongolian Medicine Research and Development, Tongliao 028000, China;Mongolian Medicine Engineering Technology Institute of Inner Mongolia, Tongliao 028000, China |
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| Abstract: | In recent years, with the steady development of Chinese pharmaceutical industry, traditional Chinese medicine (TCM) as complementary and alternative medicine preparations has won recognition and trust around the world. However, with the extensive application and in-depth research of TCM, the nephrotoxicity of TCM has attracted wide attention of scholars at home and abroad. In order to ensure the safety of clinical application of TCM, it is necessary to further study and summarize the nephrotoxic components in TCM and their toxic mechanisms. Based on the review of the literatures related to the nephrotoxicity of TCM in the past 30 years, the nephrotoxic components in TCM and their toxic mechanisms are summarized and analyzed, in order to provide ideas for the further study of nephrotoxicity of TCM and provide reference for the safe and reasonable application of TCM. |
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| Keywords: | traditional Chinese medicine nephrotoxicity toxic components toxic mechanisms safe and rational drug use |
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