ShcC proteins: Brain aging and beyond |
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| Affiliation: | 1. Laboratoire de Morphologie Fonctionnelle et Evolutive, Université de Liège, Institut de chimie, Bât. B6C, Quartier Agora, Allée du six Août 15, B-4000 Liège, Belgium;2. USR 3278 CNRS-EPHE-UPVD, Paris Sciences Lettres, CRIOBE, Moorea, French Polynesia;3. Laboratoire d''Excellence “CORAIL”, Avenue Paul Alduy 58, 66860 Perpignan, France;1. GEOMAR Helmholtz Centre for Ocean Research Kiel, Düsternbrooker Weg 20, Kiel 24105, Germany;2. Thünen Institute of Sea Fisheries, Palmaille 9, 22767 Hamburg, Germany;3. Institute of Food Safety, Animal Health and Environment BIOR, Daugavgrivas str 8, Riga LV-1048, Latvia;4. Institute of Coastal Research, Department of Aquatic Resources, Swedish University of Agricultural Sciences, Skolgatan 6, 742 42 Öregrund, Sweden;5. Ar Research Station, Department of Ecology and Genetics, Uppsala University, Visby SE-621 67, Sweden |
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| Abstract: | To date, most studies of Shc family of signaling adaptor proteins have been focused on the near-ubiquitously expressed ShcA, indicating its relevance to age-related diseases and longevity. Although the role of the neuronal ShcC protein is much less investigated, accumulated evidence suggests its importance for neuroprotection against such aging-associated conditions as brain ischemia and oxidative stress. Here, we summarize more than decade of studies on the ShcC expression and function in normal brain, age-related brain pathologies and immune disorders with a focus on the interactions of ShcC with signaling proteins/pathways, and the possible implications of these interactions for changes associated with aging. |
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| Keywords: | ShcC adaptor proteins Signaling Aging Brain ischemia Brain tumors Immunity Aβ" },{" #name" :" keyword" ," $" :{" id" :" kw0045" }," $$" :[{" #name" :" text" ," _" :" beta-amyloid AD" },{" #name" :" keyword" ," $" :{" id" :" kw0055" }," $$" :[{" #name" :" text" ," _" :" Alzheimer's disease Akt" },{" #name" :" keyword" ," $" :{" id" :" kw0065" }," $$" :[{" #name" :" text" ," _" :" protein kinase B (PKB) ALK" },{" #name" :" keyword" ," $" :{" id" :" kw0075" }," $$" :[{" #name" :" text" ," _" :" anaplastic lymphoma kinase (receptor tyrosine kinase) APP" },{" #name" :" keyword" ," $" :{" id" :" kw0085" }," $$" :[{" #name" :" text" ," _" :" alpha-amyloid precursor protein ARDs" },{" #name" :" keyword" ," $" :{" id" :" kw0095" }," $$" :[{" #name" :" text" ," _" :" age-related diseases AXL" },{" #name" :" keyword" ," $" :{" id" :" kw0105" }," $$" :[{" #name" :" text" ," _" :" receptor tyrosine kinase BCR" },{" #name" :" keyword" ," $" :{" id" :" kw0115" }," $$" :[{" #name" :" 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