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Hepatic artery infusion of high-dose melphalan at reduced flow during isolated hepatic perfusion for the treatment of colorectal metastases confined to the liver: A clinical and pharmacologic evaluation |
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| Authors: | L.B.J. van Iersel M.R. Verlaan A.L. Vahrmeijer E.L. van Persijn van Meerten F.G.J. Tijl R.W. Sparidans H. Gelderblom P.J.K. Kuppen R.A.E.M. Tollenaar C.J.H. van de Velde |
| Affiliation: | 1. Department of Clinical Oncology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands;2. Department of Surgery, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands;3. Department of Radiology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands;4. Department of Extra Corporal Circulation, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands;5. Faculty of Science, Department of Pharmaceutical Sciences, Section of Biomedical Analysis, Division of Drug Toxicology, Sorbonnelaan 16, 3584 CA Utrecht, The Netherlands |
| Abstract: | Isolated hepatic perfusion (IHP) offers the advantage of high local drug exposure with limited systemic toxicity. To increase local drug exposure, we administered melphalan at a reduced flow in the hepatic artery during IHP (hepatic artery infusion, hepatic artery–portal vein perfusion, HI–HPP). |
| Keywords: | Isolated hepatic perfusion Liver metastases Melphalan Hepatic artery infusion Colorectal cancer |
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