| 成年脑血管新生与抑郁症 |
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| 引用本文： | 张黎明,李云峰,宫泽辉. 成年脑血管新生与抑郁症[J]. 中国药理学通报, 2007, 23(6): 704-707 |
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| 作者姓名： | 张黎明 李云峰 宫泽辉 |
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| 作者单位： | 军事医学科学院毒物药物研究所,北京,100850 |
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| 基金项目： | 国家高技术研究发展计划(863计划);北京市自然科学基金 |
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| 摘 要： | 成年脑神经元再生障碍是抑郁症发生的重要的细胞生物学基础之一。近年研究发现,成年脑血管新生与神经元再生存在密切关系,成年脑血管新生(angiogenesis)是指原有的血管萌生出新的微血管,再形成新的血管的过程。多种血管新生因子尤其是血管内皮生长因子(vascular endothelial growth factor,VEGF)不仅具有促血管新生作用,还具有神经营养和神经保护以及促神经元再生的作用,可能参与抑郁症的发生与恢复,该文就脑血管新生与抑郁症关系的最新研究进展进行综述。
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| 关 键 词： | 抑郁症 血管新生 血管内皮生长因子 神经元再生 应激 |
| 文章编号： | 1001-1978（2007）06-0704-04 |
| 修稿时间： | 2007-01-30 |
Adult brain angiogenesis and depression |
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| ZHANG Li-ming,LI Yun-feng,GONG Ze-hui. Adult brain angiogenesis and depression[J]. Chinese Pharmacological Bulletin, 2007, 23(6): 704-707 |
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| Authors: | ZHANG Li-ming LI Yun-feng GONG Ze-hui |
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| Affiliation: | Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850 , China |
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| Abstract: | Down-regulation of adult hippocampal neurogenesis has been regarded as one of the important biological and cellular basis of depression. Recent studies have shown that there is a close correlation between neurogenesis and angiogenesis. Several angiogenesis factors, especially vascular endothelial growth factor (VEGF), play a vital role on angiogenesis. They not only have the neurotrophic and neuroprotective effects, but also up-regulate hippocampal neurogenesis. Thus,VEGF may be involved in the occurrence and treatment of major depression. This article reviews current understanding of the relationship between adult brain angiogenesis and depression. |
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| Keywords: | depression angiogenesis vascular endothelial growth factor neurogenesis stress |
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