新生儿重组酵母乙肝疫苗接种免疫的研究

目的：探讨重组酵母乙肝疫苗新生儿接种后抗体应答持续时间，强化复种的必要性。方法：常规对新生儿0d(出生后当天)、1月、6月接种重组酵母乙肝疫苗后检测抗体应答情况，再随机分两组，一组为强化组，一组为常规组，并随访其5年的抗体应答情况。结果：新生儿常规接种法，于12个月后有一明显抗体应答下降期(0d、1月、6月、12月)，强化组乙肝表面抗体形成率高，持续时间均高于常规接种法。结论：新生儿乙肝疫苗0d、1月、6月、12月接种法有较好的远期保护效果，对现有的0d、1月、6月新生儿乙肝疫苗常规接种法，有强化接种的必要。

Study on recombinant hepatitis B vaccine immunogenicity in infant

Objective:To investigate the antibody response to hepatitis B vaccination and the necessity of reinforcement of recombinant hepatitis B vaccine (RHBV) at 12 month. Methods:Infants were divided into two groups at random. RHBV was administered on 0 day,1 month,6 months in routine-group, and RHBV was administered on 0 day,1 month,6 months,12 months in reinforce-group. Positive rate of HbsAb titers and duration of HbsAB were measured in 12,18,30,60 months. Results:The positive rate of HbsAb of infants was lower than the reinforce-group. There is a significant difference in the duration of HbsAb of infants that the reinforce-group is much longer than routine-group(P<0005). Conclusions:In many individuals, RHBV promote a full, longer-lasting antibody response after reinforcing in 12 months.