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| 阿魏酸衍生物对心肌细胞缺氧复氧损伤的保护作用 | |
| 引用本文： | 王锦芝,黄华永,郭福晓,贾强用,郑锦鸿. 阿魏酸衍生物对心肌细胞缺氧复氧损伤的保护作用[J]. 中国热带医学, 2011, 11(12): 1505-1508 |
| 作者姓名： | 王锦芝 黄华永 郭福晓 贾强用 郑锦鸿 |
| 作者单位： | 1. 汕头大学医学院化学教研室,广东汕头,515041 2. 汕头大学医学院药理学教研室,广东汕头,515041 |
| 基金项目： | 广东省自然科学基金项目-阿魏酰哌嗪衍生物的合成及其活性研究(No.10151503102000048); 广东省自然科学基金团队项目 |
| 摘 要： | 目的探讨阿魏酸衍生物对心肌细胞缺氧复氧（H/R）损伤的影响。方法用1~3d的SD大鼠进行心肌细胞原代培养,取生长5~6d的心肌细胞分为对照组、H/R组、溶剂组、不同阿魏酸衍生物组,除对照组外其他组均做H/R模型。通过测定肌酸激酶（CK）、乳酸脱氢酶（LDH）、超氧化物歧化酶（SOD）及丙二醛（MDA）的变化,观察不同阿魏酸衍生物对心肌细胞H/R损伤的保护作用。结果与H/R比较,除IIa外,阿魏酸类似物均可明显减少心肌细胞H/R损伤所造成的CK、LDH的渗出、MDA含量,同时可增加SOD酶活力。结论阿魏酸衍生物苯环上3,5位取代基可以明显影响此类化合物抗氧化活性,甲氧基和乙氧基表现为提高活性,溴次之。 |
| 关 键 词： | 阿魏酸衍生物 缺氧复氧损伤 心肌细胞 |
Protective effect of ferulic acid analogs on hypoxia-reoxygenation injury of cardiomyocyte |
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| WANG Jin-zhi,HUANG Hua-yong,GUO Fu-xiao,et al.. Protective effect of ferulic acid analogs on hypoxia-reoxygenation injury of cardiomyocyte[J]. China Tropical Medicine, 2011, 11(12): 1505-1508 | |
| Authors: | WANG Jin-zhi HUANG Hua-yong GUO Fu-xiao et al. |
| Affiliation: | WANG Jin-zhi,HUANG Hua-yong,GUO Fu-xiao,et al.(1.Department of Chemistry,2.Department of Pharmacology,Shantou University Medical College,Shantou 515041,Guangdong,P.R.China) |
| Abstract: | Objective To study the effects of ferulic ccid analogs in a cardiomyocyte Hypoxia-reoxygenation(H/R)model.Methods The cardiomyocyte from neonatal SD rats were isolated and cultured.The H/R models of neonatal rat cardiomyocyte were established.The cardiomyocyte were randomly divided into control group,H/R group,solvent group,and Ferulic Acid analogs group.Measurements included cell damage evaluated by Lactic Acid Dehydrogenase(LDH)and Creatine Kinase(CK)release in the medium were measured,the contents of int... |
| Keywords: | Ferulic acid Hypoxia-reoxygenation Cardiomyocyte |
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