| 大鼠眼挫伤后视觉诱发电位及形态学改变的研究 |
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| 引用本文： | 耿文静,方超,王广勇,竞花兰.大鼠眼挫伤后视觉诱发电位及形态学改变的研究[J].热带医学杂志,2011,11(12):1356-1358,1382,1479. |
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| 作者姓名： | 耿文静 方超 王广勇 竞花兰 |
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| 作者单位： | 中山大学中山医学院法医病理学教研室,广东广州,510080 |
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| 摘 要： | 目的 探讨眼挫伤的电生理学和形态学改变.方法 100只SD大鼠随机分为正常对照组(10只)、损伤后1d组(50只)、损伤后10 d组(20只)和损伤后1月组(20只),制作眼挫伤模型,分别检测并记录闪光视觉诱发电位(FVEP)和图形视觉诱发电位(PVEP),P100波的潜伏期和波幅作为观察指标；取各组大鼠的眼球做常规HE染色组织学切片进行观察.结果 眼挫伤后1d、10 d及1月,FVEP和PVEP的P100波潜伏期与正常对照组比较,分别延长49.88％、53.34％、19.63％和51.87％、40.49％、17.50％,差异有统计学意义(P＜0.05)；FVEP和PVEP的P100波幅先升高后降低,损伤后1d、10d组与正常对照组比较差异有统计学意义(P＜0.05),损伤后1月组则无统计学意义(P＞0.05).损伤各组视神经可见神经纤维排列紊乱,空泡样变性,神经元周隙增宽,视神经肿胀,局灶可见胶质细胞增生;视网膜可见节细胞排列较疏松,内网层胶质细胞浸润.结论 视觉诱发电位变化与形态学改变相一致,VEP检查在眼挫伤的法医学鉴定中有重要作用.
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| 关 键 词： | 眼挫伤 视觉诱发电位 大鼠 法医学鉴定 |
Studies of changes of visual evoked potential and morphological after rat eye contusion |
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| GENG Wen-jing
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FANG Chao
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WANG Guang-yong
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JING Hua-lan.Studies of changes of visual evoked potential and morphological after rat eye contusion[J].Journal Of Tropical Medicine,2011,11(12):1356-1358,1382,1479. |
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| Authors: | GENG Wen-jing FANG Chao WANG Guang-yong JING Hua-lan |
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| Institution: | GENG Wen-jing,FANG Chao,WANG Guang-yong,JING Hua-lan ( Department of Fornesic Pathology,Zhongshan School of Medicine,Sun Yat-sen University,Guangdong,Guangzhou 510080,China) |
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| Abstract: | Objective To investigate the changes of electrophysiological and morphological from eye contusion. Methods 100 rats were used for making animal models of eye contusion and divided randomly into control group, 1 day after injury group, 10 days after injury group and the group of 1 month after injury. The changes of flashed evoked electrophysiology (FVEP) and pattern evoked electrophysiology (PVEP) were recorded. The latency and amplitude of P100 in FVEP and PVEP were observed. The eyes were sectioned and sta... |
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| Keywords: | eye contusion visual evoked potentials rats forensic identification |
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