|
|||||
|
|
| 电离辐射对大鼠耳蜗外毛细胞Prestin蛋白表达影响的实验研究 | |
| 引用本文： | 杜莎莎,任陈,田允鸿,谢国柱,刘英,孙权权,刘爱华,袁亚维. 电离辐射对大鼠耳蜗外毛细胞Prestin蛋白表达影响的实验研究[J]. 热带医学杂志, 2011, 11(10): 1127-1130 |
| 作者姓名： | 杜莎莎 任陈 田允鸿 谢国柱 刘英 孙权权 刘爱华 袁亚维 |
| 作者单位： | 1. 南方医科大学南方医院放疗科,广东广州,510515 2. 南方医科大学南方医院呼吸科,广东广州,510515 |
| 基金项目： | 广东省科技计划国际合作项目(2010B050700021) |
| 摘 要： | 目的 探讨电离辐射下大鼠耳蜗外毛细胞Prestin蛋白表达的改变及意义.方法 建立大鼠耳放射损伤模型,检测其听力复合动作电位(CAP)阈值及畸变产物耳声发射(DPOAEs)幅值,验证其电离辐射晚期感音神经性耳聋(SNHL)的发生.提取大鼠耳蜗组织mRNA及蛋白,荧光实时定量PCR检测耳蜗Prestin蛋白mRNA水平的... |
| 关 键 词： | 感音神经性耳聋 外毛细胞 Pestin蛋白 |
Effect of ionizing radiation on the Prestin expression in the rat cochlear outer hair cells |
|
| DU Sha-sha,REN Chen,TIAN Yun-hong,XIE Guo-zhu,LIU Ying,SUN Quan-quan,LIU Ai-hua,YUAN Ya-wei. Effect of ionizing radiation on the Prestin expression in the rat cochlear outer hair cells[J]. Journal Of Tropical Medicine, 2011, 11(10): 1127-1130 | |
| Authors: | DU Sha-sha REN Chen TIAN Yun-hong XIE Guo-zhu LIU Ying SUN Quan-quan LIU Ai-hua YUAN Ya-wei |
| Affiliation: | DU Sha-sha1,REN Chen1,TIAN Yun-hong1,XIE Guo-zhu1,LIU Ying1,SUN Quan-quan1,LIU Ai-hua2,YUAN Ya-wei1 (1.Department of Radiation Oncology,Nanfang Hospital,Southern Medical University,Guangdong,Guangzhou 510515,2.Department of Respiratory Diseases,China) |
| Abstract: | Objective To investigate the effect of ionizing radiation on the expression level of Prestin protein in rat cochlear outer hair cells and its significance. Methods We established a rat model of radiation injury on the ear, and then detected its hearing compound action potential (CAP) thresholds and distortion product otoacoustic emissions (DPOAEs) amplitude to verify the sensorineural hearing loss (SNHL) after ionizing radiation.After extracting the total mRNA and protein of rat cochlea,we detected the Pres... |
| Keywords: | sensorineural hearing loss outer hair cells Prestin protein |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |