不同体重多囊卵巢综合征患者内分泌和代谢相关指标分析

目的:比较不同体重多囊卵巢综合征(polycystic ovarian syndrome,PCOS)患者内分泌和代谢特点差异,为早期、科学合理诊治提供理论依据。方法:选取2007年11月～2009年9月我院就诊育龄期PCOS患者92例,按体重指数(BMI)分为<23kg/m2组(体重正常组)45例,23～25kg/m2组21例,≥25kg/m2组(肥胖组)26例,检测各组PCOS患者的血清基础性激素、血糖及胰岛素水平,并对3组的内分泌和代谢相关指标进行对比。结果:PCOS患者BMI 23～25kg/m2组和≥25kg/m2组睾酮(T)水平、胰岛素(INS)水平及胰岛素抵抗指数(IR)发生率均较BMI<23kg/m2组高,差异有统计学意义(P<0.05～0.01);BMI≥25kg/m2组INS水平较BMI 23～25kg/m2组高,差异有统计学意义(P<0.01);BMI≥25kg/m2组糖脂异常发生率较BMI<23kg/m2组高,差异有统计学意义(P<0.01)。结论:不同体重PCOS的临床表现和生化特征存在差异,肥胖PCOS患者存在更严重的内分泌紊乱。

Analysis of endocrine and metabolic characteristics of the different weight women with polycystic ovary syndrome

Objective: To compare the characteristics of endocrine and metabolic of the different weight women with polycystic ovary syndrome(PCOS)for the purpose of providing theoretical basis for early diagnosis and reasonable treatment PCOS.Methods: 92 patients in childbearing age with PCOS from November 2007 and September 2009 at our hospital were selected.PCOS patients were divided into three groups according to the body mass index(BMI) as BMI<23,23≤BMI<25 and BMI≥25.The level of based serum hormone,glucose and insulin were detected and the indexes of endocrine and metabolic in the three groups were compared.Results: Testosterone in PCOS patients both in 23≤BMI<25 group and BMI≥25 group were higher than that in BMI<23 group(P<0.05).Insulin and the prevalence of insulin resistance of PCOS patients in 23≤BMI<25 group and BMI≥25 group were higher than those in BMI<23 group(P<0.01).The prevalence of dyslipidemia of PCOS patients in BMI≥25 group were higher than that in 23≤BMI<25 group(P<0.01).Conclusions:The clinical manifestation and biochemical characteristics of PCOS for populations in different regions are different.PCOS patients with obesity have more serious endocrine disorders.