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| 环孢素A对大鼠急性脊髓损伤后Nogo-A表达的影响 | |
| 引用本文： | 曾清东,王国荣,林宗锦,陈国仙,许卫红. 环孢素A对大鼠急性脊髓损伤后Nogo-A表达的影响[J]. 海南医学院学报, 2011, 0(11): 1445-1448. DOI: 46-1049/R.20110916.1606.00 |
| 作者姓名： | 曾清东 王国荣 林宗锦 陈国仙 许卫红 |
| 作者单位： | 1. 福建省莆田市第一医院骨科,福建莆田,351100 2. 福建医科大学附属第一医院,福建福州,350004 |
| 基金项目： | 莆田市科技局科研立项基金项目(2009D03)~~ |
| 摘 要： | 目的：探讨急性脊髓损伤后应用环孢素A(CsA)对Nogo-A表达的影响。方法：建立大鼠急性脊髓损伤实验动物模型，将大鼠随机分成单纯椎板切除组（对照组）、脊髓损伤组（损伤组）、脊髓损伤后CsA治疗组（治疗组），治疗组通过腹腔注射CsA，在术后6、12 h及1、3、7、14 d处死大鼠，取材，取受损节段脊髓行HE染色及免疫... |
| 关 键 词： | 脊髓损伤 环孢素A Nogo-A 大鼠 |
Effect of cyclosporine A on expression of Nogo-A after acute spinal cord injury in rats |
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| ZENG Qing-dong,WANG Guo-rong,LING Zong-jin,CHEN Guo-xian,XU Wei-hong. Effect of cyclosporine A on expression of Nogo-A after acute spinal cord injury in rats[J]. Journal of Hainan Medical College, 2011, 0(11): 1445-1448. DOI: 46-1049/R.20110916.1606.00 | |
| Authors: | ZENG Qing-dong WANG Guo-rong LING Zong-jin CHEN Guo-xian XU Wei-hong |
| Affiliation: | ZENG Qing-dong1,WANG Guo-rong1,LING Zong-jin1,CHEN Guo-xian1,XU Wei-hong2 (1.Department of Orthopaedics,No.1 PuTian Municipal Hospital,PuTian 351100,China,2.No.1 Affiliated Hospital of Fujian Medical University,Fujian 350004,China) |
| Abstract: | Objective: To investigate the effect of cyclosporine A on expression of Nogo-A after spinal cord injury in rats.Methods: An experimental rat model of acute spinal cord injury was established.Rats were randomly divided into the control group,the injury group and the CsA-treated group,Rats were sacrificed and intubated for reperfusion at different time points after modeling.The structure of the rat spinal cord was detected by HE staining.The expression of Nogo-A in the rat spinal cord was detected by immunohi... |
| Keywords: | Spinal cord injury Cyclosporin A Nogo-A Rat |
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