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| CETP基因I405V突变位点多态性与冠心病关系的再探讨 | |
| 引用本文： | 周代锋,张勇,蔡苗,麦明晓,张云霞. CETP基因I405V突变位点多态性与冠心病关系的再探讨[J]. 海南医学院学报, 2011, 17(10): 1297-1299. DOI: 46-1049/R.20110801.1014.001 |
| 作者姓名： | 周代锋 张勇 蔡苗 麦明晓 张云霞 |
| 作者单位： | 1. 海南医学院生物化学教研室,海南海口,571101 2. 海南省老年病医院,海南海口,571101 |
| 基金项目： | 海南省科技计划资助项目(ZDXM20090805); 海南医学院生物化学与分子生物学重点学科项目; 海南省老龄办资助项目; 海南省自然科学基金立项课题(NO.80311)~~ |
| 摘 要： | 目的:以百岁老人为健康对照对CETP基因I405V突变位点多态性与冠心痛关系进行再探讨.方法:利用等位基因特异性PCR技术,对334例海南汉族CHD患者及276名百岁健康老人CETP基因I405V突变位点多态性进行检测,并利用SPSS13.0软件对检测结果进行统计学分析.结果:两组I405V基因型及等位基因频率分布比较... |
| 关 键 词： | 胆固醇酯转运蛋白基因 DNA态性 冠状动脉粥样硬化性心脏病 |
Correlation between polymorphism of mutable point in I405V of CETP gene and CHD |
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| ZHOU Dai-feng,ZHANG Yong,CAI Miao,MAI Ming-xiao,ZHANG Yun-xia. Correlation between polymorphism of mutable point in I405V of CETP gene and CHD[J]. Journal of Hainan Medical College, 2011, 17(10): 1297-1299. DOI: 46-1049/R.20110801.1014.001 | |
| Authors: | ZHOU Dai-feng ZHANG Yong CAI Miao MAI Ming-xiao ZHANG Yun-xia |
| Affiliation: | ZHOU Dai-feng1,ZHANG Yong2,CAI Miao1,MAI Ming-xiao1,ZHANG Yun-xia1 (1.Department of Biochemistry,Hainan Medical University,Haikou 571101,China,2.Hospital of Elder Diseases of Hainan Province,China) |
| Abstract: | Objective: To investigate the correlation between polymorphism of mutable point in I405V of Cholesterol ester transfer protein(CETP) gene and coronary artery disease(CHD).Methods: Polymorphism of mutable point in I405V of CETP was detected by allele specific-PCR(AS-PCR) in 334 CHD patients and 276 centenarians.The frequency of the genotype and allele were calculated and compared by SPSS13.0.Results: Frequency of the genotype and the allele in 334 CHD patients were significantly different from those in the h... |
| Keywords: | Cholesterol ester transfer protein gene DNA polymorphism coronary atherosclerotic heart disease |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |