IGF-I与宫内发育迟缓及其结合蛋白的关系

目的：检测宫内发育迟缓（IUGR）儿脐血胰岛素样生长因子-I（IGF-I）、胰岛素样生长因子结合蛋白-3（IGFBP-3）水平,分析这些指标的变化程度与胎儿期生长的关系。方法：将86例脐血标本分为IUGR（即小于胎龄儿）组和适于胎龄儿（AGA）组。采用放射免疫分析（RIA）测定IGF-I水平,免疫放射分析（IR-MA）测定IGFBP-3水平。两组间比较用t检验,两变量之间的关系采用相关回归分析。结果：与AGA组相比,IUGR组脐血IGF-I和IGFBP-3水平显著降低（P均〈0.01）;IGF-I、IGFBP-3均随胎龄及出生体重增加而增加（P均〈0.01）;IGFBP-3与IGF-I呈正相关（P〈0.01）。结论：脐血IGF-I和IGFBP-3的含量可作为判断新生儿生长发育程度的一项客观指标。

Relationship Between Cord Blood IGF-I, IGFBP-3 Levels and Intrauterine Growth Retardation (IUGR)

Objective To study the cord blood insulin-like growth factor-I(IGF-I) and its bindig protein-3(IGFBP-3) levels in neonates with intrauterine growth retardation(IUGR).Methods Cord serum IGF-I(with RIA) and IGFBP-3(with IRMA) levels were measured in 22 neonates with IUGR and 64 neonates with appropriate gestational age(AGA).Results Cord blood IGF-I and IGFBP-3 levels in IUGR neonates were significantly lower than those in AGA neonates(P<0.001).Among the 86 neonates studied in this article,44 were born pre-term and 42 were born full term.From the data,we could see that the cord blood IGF-I and IGFBP-3 levels in pre-term neonates were significantly lower than those in full-term neonates(P also<0.001).IGF-I and IGFBP-3 levels were mutually positively correlated(P<0.01).Conclusion Cord blood IGF-I and IGFBP-3 levels were useful indicator of neonates growth.