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| 弥漫性轴索损伤脑脊液神经元特异性烯醇化酶的动态变化及意义 | |
| 引用本文： | 魏风,陈俭,黄勤,朱晟,卢科,谢华,张英鹏. 弥漫性轴索损伤脑脊液神经元特异性烯醇化酶的动态变化及意义[J]. 中国微侵袭神经外科杂志, 2011, 16(11): 511-513 |
| 作者姓名： | 魏风 陈俭 黄勤 朱晟 卢科 谢华 张英鹏 |
| 作者单位： | 1. 广西医科大学临床第三附属医院神经外科,南宁,530031 2. 广西医科大学实验中心,南宁,530022 |
| 基金项目： | 广西卫生厅立项课题(编号:Z2009003); 南宁市科学技术局立项课题(编号:200902081C-1) |
| 摘 要： | 目的 探讨弥漫性轴索损伤(DAI)病人脑脊液神经元特异性烯醇化酶(NSE)的动态变化及其临床意义.方法 分别用放射免疫测定法检测76例DAI病人(实验组)和15例无神经系统疾病者(对照组)的脑脊液NSE含量.实验组根据入院时GCS评分分为轻型组23例、中型组27例和重型组26例.分别于颅脑损伤后12h、1d、3d、7d、14d采集脑脊液标本,分析NSE水平与颅脑损伤严重程度及预后的关系.结果 与对照组比较,轻型组伤后12 h～3 d、中型组伤后12h～7d、重型组伤后12 h～14 d的NSE水平均明显增高(P＜0.05)；重型组各时间点NSE水平明显高于轻型组和中型组(P＜0.01).随访3个月,轻型组、中型组和重型组预后不良率分别为0％、14.81％及73.08％.结论 脑脊液NSE水平可作为判断DAI损伤程度及预后的指标,并指导选择和调整治疗措施. |
| 关 键 词： | 颅脑损伤 弥漫性轴索损伤 神经元特异性烯醇化酶 脑脊液 |
Dynamic change and significance of neuron-specific enolase in cerebrospinal fluid in patients with diffuse axonal injury |
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| Wei Feng,Chen Jian,Huang Qin,Zhu Sheng,Lu Ke,Xie Hua,Zhang Yingpeng. Dynamic change and significance of neuron-specific enolase in cerebrospinal fluid in patients with diffuse axonal injury[J]. Chinese Journal of Minimally Invasive Neurosurgery, 2011, 16(11): 511-513 | |
| Authors: | Wei Feng Chen Jian Huang Qin Zhu Sheng Lu Ke Xie Hua Zhang Yingpeng |
| Affiliation: | Wei Feng1,Chen Jian1,Huang Qin2,Zhu Sheng1,Lu Ke1,Xie Hua1,Zhang Yingpeng1 1.Department of Neurosurgery,the Third Affiliated Hospital,Guangxi Medical University,Nanning,Guangxi 530031,China,2.Centre of Scientific Research,Guangxi 530022 |
| Abstract: | Objective To investigate the dynamic change and clinical significance of neuron-specific enolase(NSE) level in the cerebrospinal fluid(CSF) in patients with diffuse axonal injury(DAI).Methods The NSE levels in CSF were detected by radioimmunoassay in 76 patients with DAI(experimental group) and 15 patients without nervous system disease(control group) respectively.According to the GCS scores on admission,the patients in experimental group were divided into minor injury group(n=23),moderate injury group(n=27... |
| Keywords: | craniocerebral trauma diffuse axonal injury neuron-specific enolase cerebrospinal fluid |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |