3-氯丙二醇与2,3-氧丙醇合并用药对恒河猴副睾起始部超微结构的影响

<正> 本室以前一系列研究证明低剂量的3-氯丙二醇与2,3-氧丙醇合并用药对雄性大白鼠有抗生育作用;每10天为一疗程(前2天给药),在连续三疗程的给药(30天)中,可持续避孕。最近证明间断给药9疗程可使雄性大白鼠连续避孕,停药后在一定期限可恢复生育。

EFFECTS OF α-CHLOROHYRIN COMBINED WITH GLYCIDOL ON ULTRASTRUCTURE OF INITIAL SEGMENT OF EPIDIDYMIS IN MONKEY MACACA MULATTA

In this experiment ,5 monkeys were orally administered with 6 courses of treatments, each of which included 10 days: two days for giving drugs (α-chlorohydrin 5mg/kg + glycidol 75mg/kg for per day) and 8 days for discontinuing drugs. Another 3 monkeys without treatment were used as controls. The specimens were taken from the left and the right epididymis at the end of 3rd and 6th course of treatment respectively, and prepared with a routine procedure for examination under electron microscope. Marked atrophy of Golgi complex, dilation and vesiculation of rough endoplasmic reticulum and swelling of secretory granules could be observed in principal cells at initial segment of epididymis. There was no distinct difference between 3rd and 6th courses of treatment. These results suggest that the lower doses of α-chlorohydrin combined with the lower doses of glycidol have effects on initial segment of epididymis in monkeys. Additionally, such alterations of the Golgi complex and rough endoplasmic reticulum in the principal cells would reflect reduction of synthesis and secretion of substances which is needed for maturation of spermatozoa in epididymis lumen.