| 食管癌MAL基因变化的RNA原位杂交研究 |
| |
| 引用本文： | 王子平,王明荣,徐昕,许智雄,韩亚玲,蔡岩,孙燕,吴旻. 食管癌MAL基因变化的RNA原位杂交研究[J]. 中华医学遗传学杂志, 2000, 17(5): 329-331 |
| |
| 作者姓名： | 王子平 王明荣 徐昕 许智雄 韩亚玲 蔡岩 孙燕 吴旻 |
| |
| 作者单位： | 北京,中国医学科学院,中国协和医科大学肿瘤研究所分子肿瘤学国家重点实验室100021 |
| |
| 基金项目： | "863”重大项目基金(Z19-02-01-03)和"九五”攻关项目基金(96-906-01-22) |
| |
| 摘 要： | 目的 观察食管癌组织及癌旁粘膜ＭＡＬ基因ｍＲＮＡ的表达情况。方法 非放射性ＲＮＡ原位杂交。结果 ３３例配对标本中食管粘膜全部表达ＭＡＬ基因，而只有８例食管癌组织表达，表达与否与临床参数无关。结论 ＭＡＬ基因的表达下调可能是食管癌发生中的重要事件。
|
| 关 键 词： | 食管癌 MAL基因 原位杂交 mRNA |
| 修稿时间： | 1999-10-02 |
Studies of MAL gene in human esophageal cancer by RNA in situ hybridization |
| |
| WANG Ziping,WANG Mingrong,XU Xin,XU Zhixiong,HAN Yaling,CAI Yan,SUN Yan,WU Min.. Studies of MAL gene in human esophageal cancer by RNA in situ hybridization[J]. Chinese journal of medical genetics, 2000, 17(5): 329-331 |
| |
| Authors: | WANG Ziping WANG Mingrong XU Xin XU Zhixiong HAN Yaling CAI Yan SUN Yan WU Min. |
| |
| Affiliation: | Department of Molecular Oncology, Institute of Cancer, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021 P.R.China. wangmr@pubem.cicams.ac.cn |
| |
| Abstract: | Objective To observe the expression of MAL gene mRNA in esophageal cancer tissue and adjacent epithelial mucosa. Methods Non radioactive RNA in situ hybridization. Results MAL gene was expressed in all epithelia of 33 matched samples but only in 8 of esophageal cancer tissues. Differential expression between esophageal cancer tissues and adjacent epithelia was not related to clinical parameters. Conclusion Down regulation of MAL may be an important event in the development of esophageal cancer. |
| |
| Keywords: | esophageal cancer MAL gene in situ hybridization |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
