| 盐酸替扎尼定的合成 |
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| 引用本文： | 徐加,沈怡,向玲,邓勇. 盐酸替扎尼定的合成[J]. 中国医药工业杂志, 2005, 36(10): 593-595 |
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| 作者姓名： | 徐加 沈怡 向玲 邓勇 |
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| 作者单位： | 四川大学华西药学院,四川,成都,610041 |
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| 摘 要： | 4-氯-2-硝基苯胺依次经还原、缩合成环、硝化、还原制倒丶屑涮?-氯-4-氨基-2,1,3-苯并噻二唑,再与1-乙酰基咪唑烷-2-酮缩合、水解、成盐制得盐酸替扎尼定,总收率46%.
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| 关 键 词： | 替扎尼定 肌肉松弛药 合成 |
| 文章编号： | 1000-8255（2005）10-0593-03 |
| 收稿时间： | 2005-03-04 |
| 修稿时间： | 2005-03-04 |
Synthesis of Tizanidine Hydrochloride |
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| XU Jia,SHEN Yi,XIANG Ling,DENG Yong. Synthesis of Tizanidine Hydrochloride[J]. , 2005, 36(10): 593-595 |
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| Authors: | XU Jia SHEN Yi XIANG Ling DENG Yong |
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| Abstract: | Tizanidine hydrochloride was synthesized from 4-chloro-2-nitroaniline by reduction with Zn/NaOH,cyclization, nitration and reduction of nitro group with Fe/HOAc to afford 5-chloro-4-amino-2,1,3-benzothiadiazole which subsequently subjected to condensation with 1-acetyl-2-imidazolidinone, hydrolysis and then HCl salt formation with an overall yield of 46%. |
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| Keywords: | tizanidine muscular relaxant synthesis |
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