| 一种评价抗心律失常药物疗效的新方法 |
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| 引用本文： | 单其俊,白曼颐,宋有城,方卫华,陶萍. 一种评价抗心律失常药物疗效的新方法[J]. 南京医科大学学报(自然科学版), 1992, 0(3) |
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| 作者姓名： | 单其俊 白曼颐 宋有城 方卫华 陶萍 |
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| 作者单位： | 中国医学科学院心血管病研究所 阜外医院，中国医学科学院心血管病研究所 阜外医院，中国医学科学院心血管病研究所 阜外医院，中国医学科学院心血管病研究所 阜外医院，中国医学科学院心血管病研究所 阜外医院 南京医学院第一附属医院心脏内科 |
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| 摘 要： | 为了把室早的自然变异与真正的抗心律失常药物的疗效区别开来,需建立一种评价抗心律失常药物的客观标准。我们用直线回归的统计学模型研究了35例患者室早的自然变异。研究的结果表明室早自然变异的百分率分别为68%和82%(单尾95%和99%的可信限),因此,用抗心律失常药物治疗后,室早频度至少需要减少≥68%或82%,才能说明是真正的药物效应而非自然变异。同时我们用这一模型评价了口服心律平的临床疗效,心律平治疗后,分别有20例和19例患者,室早频度减少≥68%和82%,依此标准心律平的疗效分别为57%和54%(20/35、19/35)。
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| 关 键 词： | 抗心律失常药 心律平 室性心律失常 回归分析 |
A New Method for Evaluating Antiarrhythmic Drug Efficacy |
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| Shan Qijun Bai Manyi Song Youcheng Cardiovascular Institute and Fu Wai Hospital,Chinese Academy of Medical Sciences,Beijing. A New Method for Evaluating Antiarrhythmic Drug Efficacy[J]. Acta Universitatis Medicinalis Nanjing, 1992, 0(3) |
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| Authors: | Shan Qijun Bai Manyi Song Youcheng Cardiovascular Institute Fu Wai Hospital Chinese Academy of Medical Sciences Beijing |
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| Abstract: | To devolopan an objective standard for distinquishing antiarrhythmic drug effect from spontaneous variability of premature ventricular complexes (VPCs).We have studied VPCs spontaneous variability of thirty five patients with linear regression analysis method.Our results showed that VPCs spontaneous variability was 68% and 82% (95% and 99% one-tailed confidence).Therefore,the true antiarrhythmic drug efficacy is that VPCs frequency must reduce 68% and 82% or more after treatment.Based on this method,we have evaluated clinical efficacy of oral propafenone.After treatment of propafenone twenty and nineteen patients have more than 68% and 82% reduction in VPCs frequency.Propafenone efficacy is 57% and 54%(20/35, 19/35). |
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| Keywords: | anti-arrhythmia agents propafenone ventricular arrhythmias regression analysis |
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