| 汉防己甲素治疗野百合碱诱发大鼠肺动脉高压的作用研究 |
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| 引用本文： | 张尚福,孙本韬,张杰,李俸媛,雷松,程德云,杨小东,谭永淑,姚先莹,李廷谦,陈文彬. 汉防己甲素治疗野百合碱诱发大鼠肺动脉高压的作用研究[J]. 四川大学学报(医学版), 1995, 0(4) |
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| 作者姓名： | 张尚福 孙本韬 张杰 李俸媛 雷松 程德云 杨小东 谭永淑 姚先莹 李廷谦 陈文彬 |
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| 作者单位： | 山西医学院电镜室 |
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| 基金项目： | 国家“八·五”攻关资助 |
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| 摘 要： | 以野百合碱复制Ｗｉｓｔａｒ大鼠肺动脉高压模型，观察汉防己甲素对其血流动力学的作用及对肺腺泡内动脉的影响。结果表明：汉防己甲素可使肺动脉收缩压、右心室收缩压及右心房收缩压分别降低２８．０％、２８．３％及３１．５％；并使肺腺泡内动脉内皮细胞空泡变减少，内皮下腔减少和缩小，中膜胶原纤维和平滑肌细胞亦减少，使其管壁变薄。
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| 关 键 词： | 汉防己甲素，野百合碱，肺动脉高压，大鼠 |
Effect of Tetrandrine on Pulmonary Hypertension Induced by Monocrotaline in Rats |
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| Zhang Shangfu,Sun Bentao, Zhang Jie,Li Fengyuan,Lei Song,Cheng Deyun,Yang Xiaodong,Tan Yongshu,Yao Xianying,Li Tingqiar,Chen Wenbin. Effect of Tetrandrine on Pulmonary Hypertension Induced by Monocrotaline in Rats[J]. Journal of Sichuan University. Medical science edition, 1995, 0(4) |
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| Authors: | Zhang Shangfu Sun Bentao Zhang Jie Li Fengyuan Lei Song Cheng Deyun Yang Xiaodong Tan Yongshu Yao Xianying Li Tingqiar Chen Wenbin |
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| Abstract: | The effects of Tetrandrine (Tet)on in-traacinous pulmonary arteries (IAPA)and bemody-namics were studied by means of a rat pulmonary hy- pertension medel induced by monocrotaline. The re- sults showed that Tet could reduce the contractivepressure of pulmonary artery.right ventricle and rightatrium of heart by 28.0%, 28.3%,and 31.5%re- spectively. It could also decrease the vacuolar degener-ation of endoepithelial cells of IAPA,the endoepithe- lial subcavity,the collagens of medial membrane andthe numbers of smooth muscles of IAPA. |
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| Keywords: | Tetrandrine Monocrotaline Pulmonary hypertension Rat |
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