| 大剂量氨甲喋呤並醛氢叶酸救援疗法的临床观察——102例报告 |
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| 引用本文： | 喻丽华,管忠震,赵香兰.大剂量氨甲喋呤並醛氢叶酸救援疗法的临床观察——102例报告[J].癌症,1991(6). |
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| 作者姓名： | 喻丽华 管忠震 赵香兰 |
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| 作者单位： | 中山医科大学附属肿瘤医院内科，中山医科大学附属肿瘤医院内科，中山医科大学临床药理教研室 广州 510060，广州 510060，广州 510089 |
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| 摘 要： | 本文报告HDMTXCFR救援疗法治疗骨肉瘤、非何杰金氏淋巴瘤等102例的临床观察,包括血药浓度监测及治疗结果。病例均经病理学确诊;共用HDMTXCFR307疗程;MTX剂量>1g/m~2者188例次(占61.2％)。63疗程进行了血药浓度监测。本组资料提示HDMTXCFR对骨肉瘤及非何杰金氏淋巴瘤中枢神经系统侵犯有一定疗效;只要注意水化,尿硷化及CF救援,此疗法是安全的。
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| 关 键 词： | 氨甲喋呤 骨肉瘤 淋巴瘤 临床观察 |
CLINICAL OBSERVATION ON 102 CASES OF HIGH DOSE METH-OTREXATE CITROVORUM FACTOR RESCUE |
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| YU Li-hua GUAN Zhong-zhen.CLINICAL OBSERVATION ON 102 CASES OF HIGH DOSE METH-OTREXATE CITROVORUM FACTOR RESCUE[J].Chinese Journal of Cancer,1991(6). |
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| Authors: | YU Li-hua GUAN Zhong-zhen |
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| Abstract: | 102 cases of malignances, all pathohistologically comfirned, were treated with high does methotrexate/citrovorum factor rescue regimen (HDMTX-CFR) were reported.Of 307 cycles of HDMTX-CFR totally used, 188 cycles(61.2%) administered greates than. Ig/M 2 dose of MTX. MTX blood concentration was monitored by microbiological assay during the treatment of 63 cycles.We concluded that HDMTX-CFR is effective for osteosarcoma and central nervous system involvement of non-Hodgkin's lymphoma, and can be used safely under serum MTX concentration monitoring and careful clinical observation. |
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| Keywords: | High Dose Methotrexate/Citrovorum rescue Osteosarcoma non-Hodg- kin's lymphoma Clinical observation |
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