Leuconoxine, kopsinitarine, kopsijasmine, and kopsinone derivatives from Kopsia |
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| Authors: | Lim Siew-Huah Sim Kooi-Mow Abdullah Zanariah Hiraku Osamu Hayashi Masahiko Komiyama Kanki Kam Toh-Seok |
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| Institution: | Department of Chemistry, University of Malaya, 50603 Kuala Lumpur, Malaysia. |
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| Abstract: | Four new indole alkaloids were obtained from two Kopsia species, 6-oxoleuconoxine (1) from the leaf extract of K. griffithii and kopsinitarine E (2), kopsijasminine (3), and kopsonoline (4) from the stem-bark extract of K. teoi. The structures of these alkaloids were determined using NMR and MS analysis. Kopsijasminine (3) showed moderate activity in reversing multidrug resistance in vincristine-resistant KB cells. |
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