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山芝麻含药血清对HepG2.2.15细胞HBV复制的抑制作用
引用本文:黄权芳,韦刚,杨辉,林兴,张士军,黄仁彬.山芝麻含药血清对HepG2.2.15细胞HBV复制的抑制作用[J].时珍国医国药,2012,23(7):1849-1850.
作者姓名:黄权芳  韦刚  杨辉  林兴  张士军  黄仁彬
作者单位:1. 广西中医学院第一附属医院,广西南宁,530023
2. 广西分析测试研究中心,广西南宁,530022
3. 广西医科大学,广西南宁,530021
基金项目:广西壮族自治区教育厅自然科学基金
摘    要:目的观察山芝麻体外抗乙型肝炎病毒(HBV)的作用。方法采用血清药理学方法,在HBV的体外细胞培养系统中(2.2.15细胞)进行山芝麻抗HBV作用观察。结果山芝麻含药血清在HepG2.2.15细胞培养中可有效地抑制细胞HBV DNA的复制,其作用呈明显的量效和时效反应关系。结论山芝麻在体外能明显抑制HBV。

关 键 词:山芝麻  乙型肝炎病毒  HepG2.2.15细胞

The Inhibitory Effect of the Serum Containing Helicteres angustifolia on HBV DNA in the HepG2.2.15 Cells
HUANG Quan-fang , WEI Gang , YANG Hui , LIN Xing , ZHANG Shi-jun , HUANG Ren-bin.The Inhibitory Effect of the Serum Containing Helicteres angustifolia on HBV DNA in the HepG2.2.15 Cells[J].Lishizhen Medicine and Materia Medica Research,2012,23(7):1849-1850.
Authors:HUANG Quan-fang  WEI Gang  YANG Hui  LIN Xing  ZHANG Shi-jun  HUANG Ren-bin
Institution:1.The First Affiliated Hospital of Guangxi Traditional Chinese Medical University,Nanning,530023,China;2.Guangxi Center for Analysis and Test Research,Nanning 530022,China;3.Guangxi Medical University,Nanning 530021,China)
Abstract:Objective To study anti-HBV activity of Helicteres angustifolia in vitro.Methods The HBV in vitro cell culture system(HepG2.2.15 cell) was used for examining the anti-HBV activity of Helicteres angustifolia with Serum-pharmacology.Results The serum containing Helicteres angustifolia could decrease the HBV DNA level in HepG2.2.15 cell,and its inhibitory effects were dose-and time-dependent.Conclusion Helicteres angustifolia can inhibit HBV DNA in vitro significantly.
Keywords:Helicteres angustifolia  HBV  HepG2  2  15 cell
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