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| 高血压性脑出血后迟发性脑水肿患者B型脑钠肽变化及临床意义 | |
| 引用本文： | 黄卫,王晔,徐丽君,邓丽影,卞合涛. 高血压性脑出血后迟发性脑水肿患者B型脑钠肽变化及临床意义[J]. 南昌大学学报(医学版), 2010, 50(1) |
| 作者姓名： | 黄卫 王晔 徐丽君 邓丽影 卞合涛 |
| 作者单位： | 南昌大学第二附属医院神经内科; |
| 基金项目： | 江西省卫生厅科技计划项目(20091115) |
| 摘 要： | 目的观察高血压性脑出血后迟发性脑水肿患者B型脑钠肽(B-type natriuretic peptide,BNP)水平的动态变化,探讨BNP水平与迟发性脑水肿的关系。方法收集40例高血压脑出血患者[其中迟发性脑水肿者18例(DE组),无迟发性脑水肿者22例(MDE组)]和19例健康人群(对照组)。在入院后当天和治疗第10天CT扫描动态检查,且在入院当天、治疗第3天和第10天,收集血浆样本测定BNP含量,同时根据美国国立卫生研究院卒中量表(NIHSS)评估神经功能损伤程度。结果入院当天DE组及NDE组BNP含量高于对照组(P<0.01);入院后DE和NDE组BNP含量均有缓慢上升;治疗第10天NDE组BNP水平较入院时显著增加(P<0.01),NDE组则较入院时显著下降(P<0.01)。血浆BNP水平变化与NIHSS评分呈正相关(r=0.706,P<0.05)。结论动态观察血浆BNP含量是早期诊断和监测高血压性脑出血后迟发性脑水肿的有效指标。 |
| 关 键 词： | B型脑钠肽 高血压性脑出血 迟发性脑水肿 |
Plasma B-type Natriuretic Peptide Levels are Associated with Delayed Edema Secondary to Hypertensive-cerebral Hemorrhage |
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| HUANG Wei,WANG Ye,XU Li-jun,DENG Li-ying,BIAN He-tao. Plasma B-type Natriuretic Peptide Levels are Associated with Delayed Edema Secondary to Hypertensive-cerebral Hemorrhage[J]. Journal of Nanchang University(Medical Science), 2010, 50(1) | |
| Authors: | HUANG Wei WANG Ye XU Li-jun DENG Li-ying BIAN He-tao |
| Affiliation: | Department of Neurology/a>;the Second Affiliated Hospital of Nanchang University/a>;Nanchang 330006/a>;China |
| Abstract: | Objective The aim of this study was to prospectively quantify the relationship between BNP levels and occurance of delayed edema after hypertensive-cerebral hemorrhage (HCH).Methods The study included 40 consecutive patients with HCH[18 of them suffering from HCH with delayed edema (DE),22 of them suffering from HCH without delayed edema (NDE)]and 19 hypertension control subjects without diseases.Delayed edema was defined by computed tomography (CT) classification.At admission and 10 days later,CT was perfo... |
| Keywords: | B-type natriuretic peptide hypertensive-cerebral hemorrhage delayed edema |
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