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Scintigraphic validation of a magnetic resonance imaging method to study gastric emptying of a solid meal in humans |
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| Authors: | C Feinle P Kunz P Boesiger M Fried W Schwizer |
| Affiliation: | Department of Internal Medicine, Division of Gastroenterology, University Hospital Zürich, Switzerland. |
| Abstract: | Background—We have previously useda magnetic resonance imaging (MRI) method to study gastric emptying ofliquids. So far, however, it has not possible to assess solid gastricemptying with this technique. Aims—To validate scintigraphicallyMRI as a method for measuring emptying of a mixed solid/liquid meal. Methods—In eight healthy subjects,gastric emptying of a solid/liquid (SM) and a liquid meal (LM) ofidentical energy content and macronutrient composition was studied byscintigraphy and MRI for 120minutes. Results—MRI and scintigraphy agreedwith respect to emptying profiles (intraclass correlationcoefficient (RI) SM: 0.988, RI, LM:0.917), t1/2 (SMMRI: 129 (9),SMScinti: 123 (11) minutes, NS; LMMRI: 100 (7),LMScinti: 110 (8) minutes, NS) and AUC (SMMRI:8999 (232), SMScinti: 8788 (277) min%, NS;LMMRI: 8819 (368), LMScinti: 8891 (321) min%, NS). Conclusions—MRI can be used tomeasure reliably gastric emptying not only of liquid but also of mixedsolid/liquid meals in humans. |
| Keywords: | magnetic resonance imaging scintigraphy gastricemptying solid meal liquid meal |