兔急性少量蛛网膜下腔出血的模型建立及影像学表现

目的 拟通过动物实验,对比分析CT和MR常规序列对急性少量蛛网膜下腔出血(SAH)的诊断敏感度,以期发现更为敏感的检查方法.方法 选用新西兰大耳白兔18只,随机分为实验组(A组、B组)、对照组(C组)采用枕大池穿刺一次注血法建立SAH模型,分别于术后2 h、48 h行CT和MR扫描,记录CT和MR常规序列对SAH的显示.结果 ①实验组A组、B组MR FLAIR序列诊断兔急性少量SAH的敏感度较MR T1WI、T2WI及CT均高;MR FLAIR序列与CT比较,两者差异有统计学意义(P<0.05).②对照组C组未见SAH.结论 ①本研究成功建立了"枕大池一次注血法"兔SAH模型,为后续的影像学研究奠定了基础.②MR FLAIR序列对急性少量SAH的诊断较CT更为敏感,可常规用于急性少量SAH的诊断.

Establishment of rabbit subarachnoid hemorrhage model and the imaging findings of a little amount of subarachnoid hemorrhage in acute phase

Objective To explore the sensitivity of a little amount of subarachnoid hemorrhage (SAH) between CT and different MR sequences through animal experiment,to find a more sensitive way to diagnosis SAH.Methods 18 healthy adult white New Zealand rabbits were randomly divided into two experimental groups(group A and group B) and one control group(group C).Rabbit SAH model was established by injecting blood into the cisterna magna one time.All rabbits underwent CT and MR scan at 2 hours,48 hours after operation.The findings on CT and different MR sequences were observed and recorded.Results ①In experimental groups(group A and group B),MR FLAIR sequences in the diagnosis of a little amount of SAH was more sensitive than that on MR T1WI,T2WI and CT in acute phase.And the diagnosis sensitivity between MR FLAIR and CT was statistically significant(P<0.05).②Abnormal signs of SAH could not be found in group C.Conclusion ①Rabbit SAH model was established successfully which will be the foundation for the follow-up study of medical imaging.②MR FLAIR sequence is more sensitive to diagnose a little amount of SAH in acute phase,and may be used in the routine diagnosis of SAH in acute phase.