西帕依固龈液治疗口臭随机对照试验的Meta分析

目的:系统评价西帕依固龈液治疗口臭的临床疗效.方法:计算机检索美国图书馆PubMed/MEDLINE、CNKI中国知网(总库)、维普期刊资源整合服务平台相关文献.根据Jadad量表对纳入文献进行质量评价.采用Cochrane协作网提供的RevMan 5.3分析软件进行Meta分析.结果:共纳入8项临床随机对照研究(RCT)、608例有口臭症状患者.依据Meta分析结果,西帕依固龈液与安慰剂比较治疗口臭的评分(organoleptic score,OS)WMD=-0.43,95％ CI(-0.57,-0.29)]、菌斑指数(plaque index,PLI) WMD=-1.59,95％ CI(-1.67,-1.51)]均显示有显著差异;西帕依固龈液与西药比较治疗口臭OSWMD =0.16,95％ CI(0.05,0.28)]效果略差且降低PLIWMD=0.10,95％ CI(0.03,0.18)]的抑菌效果也略差.西帕依固龈液与生理盐水治疗口臭临床总有效率差异有统计学意义RR:1.64,95％CI(1.11,2.42)].结论:西帕依固龈液治疗口臭疗效优于安慰剂,可有效降低口臭值和菌斑指数,与西药相比降低口臭值、抑菌方面稍显欠缺.

A Meta-analysis of randomized controlled trials on Xipayi Mouth Rinse for the treatment of halitosis

Objective:To evaluate the effectiveness of Xipayi Mouth Rinse in the treatment of halitosis.Methods:PubMed/MEDLINE,China National Knowledge Infrastructure (CNKI) (1979-2015) and Weipu Database for Chinese Technical Periodicals (1989-2013) were systemically searched.The methodological quality of the included trials was assessed based on the Jadad scale and the available data were analyzed with RevMan software (version 5.3).Results:8 studies involving 608 participants satisfied the minimum criteria for Meta-analysis.The evidence showed that the Organoleptic Score (OS) of Xipayi Mouth Rinse compared with placebo for treatment of halitosis was WMD =-0.43,95％ CI (-0.57,-0.29)],plaque index (PLI) WMD =-1.59,95％ CI (-1.67,-1.51)];the OS of Xipayi Mouth Rinse compared with western medicine WMD =0.16,95％ CI (0.05,0.28)],PLI WMD =0.10,95％ CI(0.03,0.18)];the total efficiency of Xipayi Mouth Rinse compared with normal saline wasRR:1.64,95％ CI(1.11,2.42)].Conclusion:The current clinical evidence showed that the effectiveness of Xipayi Mouth Rinse in the treatment of halitosis is higher than the Placebo,but lower than western medicine.