海马亚区T2信号对轻度认知损害治疗前后的评价研究

目的 探讨海马亚区MRI T2信号强度对轻度认知损害(MCI)患者盐酸多奈哌齐治疗前后疗效评估的价值.方法 收集MCI患者40例并随机均分为2组(治疗组及对照组).治疗组采用盐酸多奈哌齐治疗,对照组采用安慰剂治疗,治疗期为3个月.所有受试者治疗前后均行快速自旋回波T2序列,并在工作站勾画海马各亚区,测量其MRI T2信号强度并标准化,同时分析治疗组治疗前后海马各亚区MRI T2信号强度与简易精神状态检查(MMSE)评分的相关性.结果 治疗前,与对照组比较,治疗组双侧海马各亚区MRI T2信号强度差异无统计学意义.治疗后,治疗组双侧海马头部MRI T2信号强度较对照组显著降低,差异有统计学意义(P<0.05),而双侧体尾部MRI T2信号强度在治疗后差异无统计学意义.治疗组MMSE评分与治疗前后双侧海马头部MRI T2信号强度均呈负相关(P<0.05).结论 双侧海马头部MRI T2信号强度可有效评估MCI治疗后效果,可作为MCI早期诊疗有价值的辅助指标.

The evaluating value of hippocampal subfield's T2 signal intensity before and after the treatment for mild cognitive impairment

Objective To investigate the value of the hippocampal subfield's MRI T2 signal intensity in evaluating the effect of the hydrochloric donepezil for mild cognitive impairment(MCI).Methods 20 MCI patients with hydrochloric donepezil (treatment group) and 20 patients with placebo (control group) were scanned by MRI using FSE-T2 sequence.The margin of hippocampal subfields was outlined manually for each side to measure the MRI T2 signal intensity.The relationship between hippocampal MRI T2 signal intensity and MMSE scores was analyzed in the treatment group.Results Before the treatment, there was no significant difference of the MRI T2 signal intensity between groups.After the treatment, the MRI T2 signal intensity in the bilateral head of the treatment group was significantly decreased compared with the control group(P<0.05).There was an inverse relationship between the MRI T2 signal intensity of the bilateral hippocampal head and MMSE scores in the treatment group(P<0.05).Conclusion The MRI T2 signal intensity in the bilateral hippocampal head could be regarded as a valuable marker in making clinical diagnosis and evaluating the effect of the treatment for MCI in its early stage.